Single-domain anti-bodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the active of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax ...
The inhibitor of apoptosis proteins (IAP) suppress apoptosis induced by a variety of stimuli. The aims of this study were to: (a) compare the expression of X-linked IAP (Xiap) and Human IAP-2 (Hiap-2) in cervical carcinoma cells and normal cervix, (b) determine the correlation between ...
Besides selectivity of binding between some BH3-only proteins to anti-apoptotic BCL-2 family members, arguably the most cogent case for qualitative differences in the anti-apoptotic molecules is the apparent differential dependence by many immune cell subsets on individual proteins for survival. For e...
In a wide variety of human tumors, the increased expression of anti-apoptotic proteins (Bcl-2 and Bcl-(XL)) was found. Moreover, it was revealed that high levels of these proteins block the action of many chemotherapeutic drugs. Due to this fact the inhibition of anti-apoptotic function ...
(position i-9, i-8 and i+2) of BH3 peptides may be involved in their inhibitory specificity. The calculated results show the aptitude of increasing the inhibitory specificity of BH3 peptides and designing more effective Mcl-1 inhibitors.Key Words: cell apoptosis, Bcl-2 family proteins, ...
More particularly, the present invention is directed to 30K protein genes and a recombinant proteins prepared by using novel anti-apoptotic gene obtained from silkworm. The present invention also provides anti-apoptotic health care food, pharmaceutical preparation, additive for cell culture medium, and ...
Objective To study the influence of trace element iodine and selenium on the level of autoantibodies and the antioxidative capacity with autoimmune thyroiditis; to investigate the effect of iodine and selenium on the expression of apoptosis proteins with autoimmune thyroiditis; to explore and test an ...
Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Several mechanisms account for the cytoprotective effect of HSP27 and HSP70. 1)...
专利名称:ANTI-APOPTOTIC FUSION PROTEINS 发明人:KUNZENDORF, Ulrich,KRAUTWALD, Stefan 申请号:EP 0974 8796.1 申请日:20091110 公开号:EP2350121B1 公开日:20130227 摘要:The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into ...
Excerpt Pro- and anti-apoptotic proteins maintain a regulated balance in cells that allow programmed cell death to occur in response to genetic damage and other stimuli. In cancer cells, this balance is often dysregulated by the overexpression of anti-apoptotic factors. A probe development project ...