The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J. Biol. Chem. 281: 3254- 3260.Eckelman, B. P., and Salvesen, G. S. (2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J. Biol. Chem. 281, 3254 -3260...
In a wide variety of human tumors, the increased expression of anti-apoptotic proteins (Bcl-2 and Bcl-(XL)) was found. Moreover, it was revealed that high levels of these proteins block the action of many chemotherapeutic drugs. Due to this fact the inhibition of anti-apoptotic function ...
anti-apoptotic proteins rather than by a single anti-apoptotic protein. This model provides both an insight into how the sum of relative levels of anti-apoptotic proteins BCL-2, MCL-1 and A1 influence survival of T cells, B cells and dendritic cells, and a framework for ascertaining how ...
These results provide compelling evidence that phosphorylation of anti-apoptotic Bcl-2 proteins has a critical role in regulation of mitotic death. These findings make an important contribution toward our understanding of the molecular mechanisms of action of MIAs, which is critical for their rational ...
Anti-apoptotic proteins mainly include Bcl-2, Bcl-XL, Mcl-1, and Bcl-W, and except for Mcl-1, have four BH (Bcl-2 Homology) domains (BH1∼BH4), and Mcl-1 does not contain BH4 domain. Pro-apoptotic proteins can be further divided into two categories. One is multiple BH domain ...
Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Several mechanisms account for the cytoprotective effect of HSP27 and HSP70. 1)...
More particularly, the present invention is directed to 30K protein genes and a recombinant proteins prepared by using novel anti-apoptotic gene obtained from silkworm. The present invention also provides anti-apoptotic health care food, pharmaceutical preparation, additive for cell culture medium, and ...
Protein degradation, resulting from frozen storage, reduced the digestive efficiency of the pork proteins. The samples, frozen at high temperatures and stored for a long duration, exhibited a more substantial demonstration of this phenomenon.For an alternative cancer treatment approach, the combination ...
The anti-apoptotic proteins Bcl-w and Bcl-2 and the pro-apoptotic protein Bax may mediate cell death or survival via regulation of the mitochondria including second mitochondria-derived activator of caspase (Smac)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) re...
We demonstrated the crucial role of two anti-apoptotic proteins, phosphoprotein enriched in astrocytes 15 (PEA-15) and survivin, in the apoptotic outcome of this dual targeting therapy. Results Inhibition of α5β1 integrin sensitizes p53wt glioma cells to Nutlin-3a. We demonstrated that α5β1...