L. (2008) Regulation of pro-apoptotic BH3-only proteins and its contribution to cancer progression and chemoresistance. Cell Signal. 20: 1921-1926.Fernandez-Luna, J. (2008) Regulation of pro-apoptotic BH3-only proteins and its contribution to cancer progression and chemoresistance. Cell Sig- ...
Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only proteins Bim and Puma. We studied the stress pa...
We found that activation of the proapoptotic BH3-only proteins Bim and Puma in response to glucotoxicity is dependent on the induction of both ER stress and mitochondrial oxidative stress. Furthermore, consistent with our findings in mouse islets, we observed significantly more proapoptotic BH3-...
We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2....
The BH3-only members of the Bcl-2 protein family are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating th...
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor... A, O'Reilly LA, et al, Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. ... Puthalakath,Hamsa,Villunger,... - 《...
These proapoptotic BH3-only proteins may function by participating in funda- mental cellular processes,2,17,32,33 in position to sense potentially catastrophic perturbations in cell function and signal to the core apoptotic machinery. Bid has been shown to be a substrate of Atm/Atr and loss of...
The proapoptotic BH3-only proteins (e.g., BID, BIM) interact with the multidomain proapoptotic BAX and BAK, which in turn oligomerize to form a pore in the MOM that is essential for permeabilization (Wei et al. (2001) Science 292:727-730; Kuwana et al. (2002) Cell 111:331-342)....
Upon stress stimuli pro-apoptotic BH3-only proteins, such as BIM and PUMA, are induced transcriptionally or post-transcriptionally in a cell type and stimulus-specific manner, and initiate apoptosis by displacing BAX/BAK from their restraint by the pro-survival proteins and possibly also by direct...
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groo... C Lin,SN Willis,A Wei,... - 《Molecular Cell》 被引量: 3361发表: 2005年 P[sup53]- and Drug-Induced Apoptotic Responses Media...