Definition A group of proteins supporting apoptosis .DefinitionA group of proteins supporting apoptosis .apoptosisapoptosisapoptosisSpringer Berlin HeidelbergSubauste MC,Sansom OJ,Porecha N,Raich N,Du L,Maher JF.Fem1b,a proapoptotic protein,mediates proteasome inhibitor-induced apoptosis of human colon ...
Abstract Bcl-2-family proteins are central regulators of cell life and death. At least three major classes of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain several conserved regions of sequence similarity (termed ‘multidomain’). In mammals, the multidomai...
Significance: Pore size-tuning constitutes a new level for the regulation of Bax/Bak activity.The Bcl-2 proapoptotic proteins Bax and Bak mediate the permeabilization of the mitochondrial outer membrane during apoptosis. Current models consider that Bax and Bak form pores at the mitochondrial outer ...
The anti-apoptotic proteins Bcl-w and Bcl-2 and the pro-apoptotic protein Bax may mediate cell death or survival via regulation of the mitochondria including second mitochondria-derived activator of caspase (Smac)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) re...
However, activation of pro-apoptotic proteins did not lead to induction of apoptosis. These observations suggest that autophagy governs the downstream pro-apoptotic effectors to execute growth arrest in BCa cells. Induction of autophagic signalling by NA is dependent on LC3B activation. Next, we ...
The meaning of PROAPOPTOTIC is promoting or causing apoptosis. How to use proapoptotic in a sentence.
The respective overexpression and downregulation of proapoptotic proteins like cleaved caspase-8, cleaved PARP-1 and Bax and antiapoptotic proteins like Bcl-2 further validated the apoptotic pathway induced by AAL on AML cells. Finally, LC-MS revealed the presence of several compounds like fatty ...
Whereas irinotecan-induced up-regulation of the proapoptotic proteins PUMA and Noxa requires p53, we find that irinotecan inhibits Janus kinase 2 (JAK2)-... R Ravi,AJ Jain,RD Schulick,... - 《Cancer Research》 被引量: 169发表: 2004年 Hypoxia-reoxygenation-induced apoptosis in cultured adult...
Protein disulfide isomerase (PDI) family proteins are classified as enzymatic chaperones for reconstructing misfolded proteins. Previous studies have shown that several PDI members possess potential proapoptotic functions. However, the detailed molecular mechanisms of PDI-mediated apoptosis are not completely ...
Given that the pro-apoptotic proteins PCAF, ADA3, and PACS1 were significantly down regulated in tumor compared to premalignant gastric mucosa at the mRNA level, we examined the expression of the corresponding proteins by immunohistochemistry in a tissue microarray (TMA). The TMA comprised 73 resec...