A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. Biochimie, 2009, 91(4): 502-507.Yan F, Gou L, Yang J, et al (2009). A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung ...
Our original investigations in vitro and vivo indicated PNAS4 is a novel pro-apoptosis gene, which could be used as a potential target of cancer biotherapy in future. 展开 关键词: PNAS4 Apoptosis Antitumor A549 cells Lewis lung carcinoma ...
Objective:To investigate the expression of proapoptosis gene bax in primary hepatocellular carcinoma(HCC)and itsclinical significance. 目的:研究促凋亡基因 bax 在肝细胞癌(HCC)的表达及其临床意义。 更多例句>> 3) Apoptotic activity 细胞凋亡活性4...
NCBI's Gene Database shows that pro-survival members of Bcl-2family always have a high expression in breast cancer cell lines.Previous studies have shown pro-survival members of Bcl-2family would promote tumor progression.BH3 mimic is a new type of targeted inhibitor and could antagonize pro-...
Since then, it has been shown to regulate a wide range of cellular functions, including metabolism, gene expression and cytoskeletal integrity [8]. Activity of GSK-3β is regulated by phosphorylation and interaction with inhibitory proteins. The phosphorylation at a tyrosine residue (tyr216) ...
The invention comprises recombinant adenovirus of a PDCD5 gene expressing box, wherein the PDCD5 gene expressing box orderly comprises a promotor, cDNA of human PDCD5, and a terminator from upstream to downstream. SG611-PDCD5 recombinant adenovirus obtained through construction applies a human ...
Overexpression of Ash2L enhanced P53-dependent apoptosis in response to chemotherapy, associated with increased P53 pro-apoptotic gene promoter occupancy and target gene expression. In contrast, pre-silencing of Ash2L abrogated P53’s ability to induce the expression of these transcriptional targets, ...
Deathless Apoptosis / Norah's Ark(Season 2, Episode 14) Podcast Episode|11 min|Sci-Fi Edit pageAdd to list In this mini-episode we discuss a new gene therapy some are calling "the death virus", as well as a closed-loop cruise line designed just for the super elderly. Hannah Altenbach...
We have shown that LCs derived from mice deficient in the proapoptotic Bid (BH3-interacting death domain protein) gene (Bid KO) resist apoptosis and induce amplified immune responses. In this report, we examined responses in Bid KO mice to UVB exposure. Acute UV exposure led Bid KO mice ...
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