Konopleva M, Zhao S, Hu W, Jiang S, Snell V, Weidner D et al. The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells. Br J Haematol 2002; 118: 521-534....
[4] demonstrate that the beneficial effects achieved by stable cell engineering can also be obtained by simple co-transfection of anti-apoptotic genes, thereby eliminating the requirement for stable cell engineering.doi:10.1002/biot.201400104Hackl, Matthias...
The results revealed that baicalein treatment of T24 and 253J bladder cancer cells targeted the expression of mRNA and proteins corresponding to the anti-apoptotic genes. RT-PCR assay showed that anti-apoptotic genes were markedly over-expressed in the bladder cancer cells. Exposure of the bladder...
The expression of the pro-survival genes, Bcl-2 and survivin was also reduced following inhibition of β-catenin transcriptional activity, as was the expression of eNOS. In conclusion, our data demonstrate that β-catenin is a positive regulator of eNOS activity and cell survival in human ECs....
This led to decreased expression of apoptotic genes and proteins in USP13-overexpressing BMSCs. Our findings highlight USP13 as a promising target for enhancing BMSC survival and efficacy in treating MPS-induced ONFH. Graphical Abstract Open in new tabDownload slide BMSCs, steroid-induced ...
In addition cytoplasmic does not occur when AK-5 cells are transfected with anti-apoptotic genes A.S, A or which inhibit . 展开 关键词: Tumor cell apoptosis pH reduction Anti-apoptotic gene Peptide inhibitor DOI: 10.1016/S0014-5793(97)00665-0 ...
Furthermore, we found that during TNF-alpha stimulation, NF-kappaB-regulated anti-apoptotic genes were upregulated in HepG2 cells but were downregulated in HepG2.2.15 cells. Based on the previously mentioned results, we can conclude that the IKK-p-level changes induced by HBV infection modulate...
The major challenge in treating cancer is that many tumor cells carry mutations in key apoptotic genes such as p53, Bcl family proteins or those affecting ... SP Cregan,VL Dawson,RS Slack - ONCOGENE -BASINGSTOKE- 被引量: 0发表: 2004年 Caspase-independent cell death: leaving the set without...
The present invention relates to DNAs encoding anti-apoptotic 30K proteins. More particularly, the present invention is directed to 30K protein genes and a recombinant proteins prepared by using novel anti-apoptotic gene obtained from silkworm. The present invention also provides anti-apoptotic health ...
Higher expressions of Bag-1 and Bcl-2 genes were discovered in the colon carcinoma tissues. However, they were not observed in the normal tissues (Fig. 1). Expressions of Bag-1 and Bcl-2 in colon cancer The immunohistochemical staining of Bag-1 could be classified as negative, expression ...