Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitisUlcerative colitisRemissionCox analysisBiomarkersDue to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear ...
Disclosed are compositions and methods of screening for targets for antiviral chemotherapy having anti-apoptotic activity, and compositions and methods of screening for antiviral compounds that interfere with the anti-apoptotic activity of such targets. The targets comprise viral polypeptides having anti-apo...
Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors Immunoblot analysis of primary adenocarcinomas revealed expression of the anti-apoptotic proteins Bcl-2, Bcl-X(L), Mcl-1, and BAG-1, as well as the ... JM Zapata,M Krajewska,S Krajewski,....
The expanding wealth of human, model and other organism's genomic data has allowed the identification of a distinct gene family of apoptotic related genes... Lan,Hu,Temple,... - 《Apoptosis》 被引量: 80发表: 2009年 Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserv...
The aims of this study were to investigate the expressions and significance of the antiapoptotic genes Bag-1 and Bcl-2 in colon cancer and to evaluate their relationship. The expressions of Bag-1 and Bcl-2 were examined in 128 colon cancer and 20 normal colon tissue samples by reverse-transc...
Furthermore, we found that during TNF-alpha stimulation, NF-kappaB-regulated anti-apoptotic genes were upregulated in HepG2 cells but were downregulated in HepG2.2.15 cells. Based on the previously mentioned results, we can conclude that the IKK-p-level changes induced by HBV infection modulate...
The expanding wealth of human, model and other organism's genomic data has allowed the identification of a distinct gene family of apoptotic related genes... Lan,Hu,Temple,... - 《Apoptosis》 被引量: 80发表: 2009年 Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserv...
Apoptosis is a recognized limitation for generating large numbers of megakaryocytes in culture. The responsible apoptosis genes have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems. As CD34+ cells isolated from human umbilical vein cord blood were differe...
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal The caspase inhibitor ZVAD reduced not only doxorubicin-induced lethality but also the increased expression of SphK1 and secretion of S1P. Apoptotic cells ... DR Gude,SE Alvarez...
Nuclear factor-κB (NF-κB) promotes cell survival by upregulating expression of anti-apoptotic genes, a process that is antagonized by inhibitors of κB (... Y Wang,H Cui,A Schroering,... - 《Nature Cell Biology》 被引量: 181发表: 2002年 Apoptosis: Activate NF-κB or die? Activation...