Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol Ther 2006; 5: 1714-1720Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK: Dysregulation of Reg gene expression occurs early in...
To further strengthen the link of the ADAR1–XIAP regulatory axis to the process of apoptosis, we performed double knockdown experiments to assess the effect of XIAP downregulation on the ADAR1-mediated apoptotic response. While lowering ADAR1 expression reduced the levels of PI/Annexin V staining...
This list of genes includes the glutathione peroxidase (GPX), Cell Death and Differentiation The dark side of a tumor suppressor RU J¨anicke et al 964 Figure 2 Anti-apoptotic p53 targets involved in oxidative stress responses. p53 transcriptionally induces (green arrows) expression of the ...
Apoptotic cells were quantified using the Annexin V-FITC/PI Apoptosis Detection Kit (Yeasen) according to the manufacturer’s instructions and analyzed by Beckman Cytoflex. LDH release was determined using LDH Cytotoxicity Assay Kit (Yeasen) following the manufacturer’s instructions. RNA-seq and ...
Overexpression of the P53 transcription factor can induce ether cell cycle arrest or apoptosis through transcriptional regulation of several genes including the cell cycle ingibitor P21, DNA repair gene GADD45, and the apoptotic inducer Bax. P53 has also been shown to induce apoptosis by meas of...
reduced when increasing concentrations of αKG were added to the culture (Fig.2e), indicating that, as with TET2 inhibition, glutarate inhibits HIF-P4H-1 in an αKG-competitive manner. This inhibition of HIF-P4H-1 was correlated with increased expression of several HIF target genes in DEG-...
The number of yet to be characterized candidate anti-apoptotic genes identified in screens or as genes that are up-regulated in apoptotic resistant cells clearly indicates that the list is not yet complete [142], [143], [144], [145], [146], [147], [148]. It is worth mentioning that...
Importantly, YY1 plays a significant role in the regulation of anti-apoptotic gene products: Bcl-2, Bcl-xl, Mcl-1 and survivin [80,112]. These anti-apoptotic genes are of interest as their overexpression is associated with cancer therapeutic resistance as well as promoting cancer proliferation ...
Curcumin exhibits antioxidant, anti-inflammatory and anti-apoptotic potential thereby reduce neurodegenerative, cardiovascular, metabolic, gastrointestinal, respiratory and inflammatory diseases. Clinical and preclinical data have conclusively proved that curcumin modulates neurotransmitter levels and reduces ...
Re-expression of TRIM25 WT, but not PTFGAAAA, significantly promoted the expression of these genes (Fig. 7b–d). Together, these results suggest that viral infection promotes TRIM25 co-condensation with G3BP1, which in turn inhibits viral infection. Fig. 7: Co-condensation of TRIM25 and ...