DGIdb is an expert-curated database that integrates 100, 273 drug-gene interactions from 22 source databases such as DrugBank74, Drug Target Commons75, PharmGKB76, and Chembl77. It has more than 40, 000 genes and 10, 000 drugs from different drug classes. To filter the interacting drugs ...
Researchers at Washington University School of Medicine in St. Louis have created a massive online database that matches thousands of genes linked to cancer and other diseases with drugs that target those genes. Some of the drugs are approved by the U.S. Food and Drug Administration, while oth...
We developed the COVID19db platform ( http://hpcc.siat.ac.cn/covid19db & http://www.biomedical-web.com/covid19db ) that provides 39 930drug–target–pathway interactions and 95 COVID-19 related datasets, which include transcriptomes of 4127 human samples across 13 body sites associated ...
PharmMapper hosts a large, in-house repertoire of pharmacophore database (namely PharmTargetDB) annotated from all the targets information in TargetBank, BindingDB, DrugBank and potential drug target database, including over 7000 receptor-based pharmacophore models (covering over 1500 drug targets ...
PharmMapper hosts a large, in-house repertoire of pharmacophore database (namely PharmTargetDB) annotated from all the targets information in TargetBank, BindingDB, DrugBank and potential drug target database, including over 7000 receptor-based pharmacophore models (covering over 1500 drug targets ...
DrugBank [19], [20] and Therapeutic Target Database (TTD) [21] are important databases for finding proteins that are targeted by drugs and inhibitors, using BLAST search of an e-value of 10−5. Functional prediction Uncharacterized proteins that are novel drug targets as predicted by the ...
Several approaches have been discovered which can target GSK-3 protein like targeting it via LiCl salts and/or 6-bromoindirubin-3'-oxime (BIO).Thus, the development of GSK-3 inhibitors has received attention as an attempt to control both the spread of the disease and its severity. 展开 ...
Finally, drug-target databases were inquired to prioritize the druggable targets, and a phenome-wide MR was conducted to evaluate the drug safety and repurposing. Methods Overall design The workflow and methodology of this study are outlined in Fig. 1. In brief, cis-pQTL data derived from six...
Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target. This is a preview of subscription content, access via your ...
PharmMapper hosts a large, in-house repertoire of pharmacophore database (namely PharmTargetDB) annotated from all the targets information in TargetBank, BindingDB, DrugBank and potential drug target database, including over 7000 receptor-based pharmacophore models (covering over 1500 drug targets ...