Update of TTD: Therapeutic Target Database. Increasing numbers of proteins, nucleic acids and other molecular entities have been explored as therapeutic targets, hundreds of which are targets of appr... Feng,Zhu,BuCong,... - 《Nucleic Acids Research》 被引量: 550发表: 2010年 Update of TTD:...
We subsequently explored the Drug Gene Interaction Database and identified currently available small molecule inhibitors targeting genes from the TPX2/TTK network (Table S10). Our analysis identified three currently available drugs targeting TTK, however no drugs were found to target TPX2 (Fig. 8b...
LRG1 as a novel therapeutic target in eye disease Article Open access 05 January 2022 Data availability Requests for additional information, reagents or material resources should be addressed to P.S. Sequencing data from STZ-treated mouse retinas have been deposited in NCBI’s Gene Expression Om...
RAS genes are the most commonly mutated oncogenes in cancer, but effective therapeutic strategies to target RAS-mutant cancers have proved elusive. A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, leading researchers to test numerous alternative...
The primary active components of PNS were tested utilizing the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Analysis Platform based on oral bioavailability and drug-likeness. The target databases for knee osteoarthritis were created using GeneCards and Online Mendelian Inheritance ...
Diverse areas of therapeutics development: TDC covers a wide range of learning tasks, including target discovery, activity screening, efficacy, safety, and manufacturing across biomedical products, including small molecules, antibodies, and vaccines. ...
Furthermore, knock-down of METTL7B by GNC-siRNA re-sensitized LUAD cells to gefitinib and osimertinib both in vitro and in vivo. Overall, this study provides new insights into the molecular targeted therapy and potential target for reversing EGFR-TKIs resistance in LUAD....
After the protein concentration was determined, the cell lysate was quantified to a total protein amount of 2 mg, and the primary antibody was added to the cell lysate at a ratio of 1:100, incubated overnight at 4°C to bind the antibody to the target protein. The next day, the ...
Syndecan-4 (SDC4) functions as a major endogenous membrane-associated receptor and widely regulates cytoskeleton, cell adhesion, and cell migration in human tumorigenesis and development, which represents a charming anti-cancer therapeutic target. Here, SDC4 was identified as a direct cellular target ...
therapeutic target. To reverse the malignancy due to KK-LC-1 expression, we employ a computational approach and discover Z839878730 (Z8) as an small-molecule inhibitor which may disrupt KK-LC-1 and FAT1 binding. We demonstrate that Z8 suppresses TNBC tumor growth via a mechanism that ...