The Therapeutic Target Database: an internet resource for the primary targets of approved, clinical trial and experimental drugs. Expert Opin Ther Targets. 2011; 15:903-12.The Therapeutic Target Database: an Internet resource for the primary targets of approved, clinical trial and experimental ...
https://www.omim.org/), the Pharmacogenetics and Pharmacogenomics Database (PharmGkb,https://www.pharmgkb.org), the Therapeutic Targets Database (TTD,http://db.idrblab.net/ttd/), and the Drugs and Drug Target Information Databases DM-related disease target ...
Methods To this end, we developed checkpoint therapeutic target database (CKTTD), the first comprehensive database for immune checkpoint targets (proteins, miRNAs and LncRNAs) and their modulators. A scoring system was adopted to filter more relevant targets with high confidence. In addition, a ...
covering the physical, chemical, biological and medical sciences. He has authored over 270 publications in the interdisciplinary database Journal Citation Reports. He has served as Visiting Professor at, e.g., Cornell University, North Carolina State University, and the University...
Small cell lung cancer (SCLC) lacks effective treatments to overcome chemoresistance. Here we established multiple human chemoresistant xenograft models through long-term intermittent chemotherapy, mimicking clinically relevant therapeutic settings. We s
molecules that target nearly every step of the coagulation pathway have been developed. Among these molecules, inhibitors of factor XII (FXII) or factor XI (FXI) are promising alternatives as deficiencies in these factors protect against thrombosis without causing spontaneous hemorrhage, as revealed by...
TCM has also been regarded as having a preventive effect on irAEs in addition to its therapeutic benefit. According to Xu Q [107], Chinese medicine external treatment reduced the incidence of ICI-related cutaneous adverse events (treatment group vs. control group: 29.17% vs. 58.33%,P = ...
According to the intersection from Venn diagram, we found 117 targets that may be related to the therapeutic effects of CO on RA (Fig. 3a). Next, we submitted the 117 overlapping genes into the STRING database to construct a PPI network. The results demonstrated that there were 117 nodes ...
To reduce the chance of identifying false-positives, we overlapped TFs surveyed in consensus target genes existing in ChEA, the ENCODE gene-set library and the hTFtarget database. The expression correlation between SLC2A12 and the overlapping TF genes in GSE122897 was plotted. To identify the ...
Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of efficacy on early target selection1. Drug targets with genetic support are more likely to be therapeutically valid2,3, but the translational use of genome-scale data such as from genome-wide associat...