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7,8. We considered that drug target genes are able to provide key information for the mechanism. Each drug has a set of target genes (or target gene products), with which the drug interacts to modify their actions
Systemic/target tissue exposure is an important concept when interpreting in vivo study results, especially when negative in vivo results follow convincingly positive results in an in vitro mammalian assay or when no in vitro mammalian test is included (i....
Cellecta offers a suite of genomic products & services: Functional screens. Lentiviral constructs & libraries. Clonal barcodes. Transcriptome & adaptive immune repertoire profiling and more. We power your drug target identification, validation, and bioma
(A) Shows the intersection of results where the diagnosis of the association matched the diagnosis used for the drug targeting the gene of the DrugBank database. A total of 874 associations had a match between the target gene, associated phenotype, and the diagnosis that drugs are prescribed to...
The global set of relationships between protein targets of all drugs and all disease-gene products in the human protein–protein interaction or 'interactome' network remains uncharacterized. We built a bipartite graph composed of US Food and Drug Administration–approved drugs and proteins linked by ...
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•Target Importance and Novelty Explorer (TIN-X),用于根据从科学文献中挖掘的文本数据,可视化 Pharos 中疾病与潜在药物靶点之间的关联。•目标GWAS分析(TIGA),一种通过合理直观的评估指标总结全基因组关联研究(GWAS)得出的基因-性状关联的工具。18•组织表达可视化工具,从多个来源提取表达数据,并将这些数据可视化...
DSigDB: drug signatures database for gene set analysis We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17...
Real-world pharmacovigilance study of drug-induced autoimmune hepatitis from the FAERS database Bu-kun Zhu , Si-ying Chen & Wei Zhang Article 29 January 2025 | Open Access Assessment of Hsp90β-selective inhibitor safety and on-target effects Tyelor S. Reynolds , Sanket J. Mishra &...