Ch KK, Jamil K, Raju GS (2011) Predicting drug-target interaction in cancers using homology modeled structures of MTHFR gene . Biology and Medicine 3 : 70–81Ch Kalyan K., Kaiser Jamil G.S.Raju (2011) Predicting drug-target interaction in cancers using homology modeled structures of MTHFR ...
drugs and protein targets. different from chemogenomic-based models, network-based models encode drug and target representations by integrating heterogeneous information from multiplex functional interaction networks, such as inducible gene expression, drug side effects, related diseases, and genetic ...
7,8. We considered that drug target genes are able to provide key information for the mechanism. Each drug has a set of target genes (or target gene products), with which the drug interacts to modify their actions
Besides its vital role in carcinogenesis, TME is also a better drug target because of its relative genetic stability with lesser probability for the ... R Agarwal,G Deep - 《Current Cancer Drug Targets》 被引量: 62发表: 2013年 Chemogenomic Approaches to Elucidation of Gene Function and Geneti...
With very few exceptions, in order for a drug to affect the function of acell, an interaction at themolecularlevel must occur between the drug and some target component of the cell. In most cases the interaction consists of a loose, reversible binding of the drug molecule, although some dr...
and protein–pathway associations) is considered as an edge type. The KG stores the information in a triplet form where each triplet represents an interaction/association between two unique entities (e.g., aspirin, drug–target interaction, COX1). After constructing the KG infrastructure, we used...
BMC Bioinformatics (2023) 24:488 https://doi.org/10.1186/s12859-023-05593-6 BMC Bioinformatics RESEARCH Open Access Advancing drug–target interaction prediction: a comprehensive graph‑based approach integrating knowledge graph embedding and ProtBert pretraining Warith Eddine Djeddi1,2*, ...
Drug-target interaction (DTI) prediction has become a crucial prerequisite in drug design and drug discovery. However, the traditional biological experiment is time-consuming and expensive, as there are abundant complex interactions present in the large size of genomic and chemical spaces. For alleviat...
drug targetintractable epilepsynetworkmoduleGene OntologyKEGG pathwayEpilepsy is one of the common nervous system diseases and a complex brain disease that ... H Chu,X Zhou,G Liu,... - IEEE 被引量: 2发表: 2014年 Analysis and prediction of protein stability based on interaction network, gene ...
Many drugs known or suspected to cause fetal harm are tolerated in adults43, and might target developmentally important genes. Constraint is thought to primarily reflect selection against heterozygotes13, the effective gene dosage of which may differ from that achieved by a drug. Constraint measures...