Alberts, A. S., and A. Schonthal. Positive and negative regulation of cell cycle progression by serine threonine protein phosphatases. In V. Hu (ed.), The cell cycle: regulators, targets, and clinical applications, in press. Plenum, New York....
Furthermore, induction of activated K-down-regulated p27and up-regulated p53. Up-regulation of p53 was correlated with enhanced p53 transactivation and accompanied by up-regulation of p21and Gadd 45, two p53 effectors and negative cell cycle regulators. In addition, activated K-up-regulatesbut ...
Mechanisms That Regulate the Cell Cycle Status of Very Primitive Hematopoietic Cells in Long-Term Human Marrow Cultures. II. Analysis of Positive and Negative Regulators Produced by Stromal Cells Within the Adherent Layer Author links open overlay panelConnie J. Eaves, Johanne D. Cashman, Robert J...
Future studies will likely identify additional mTORC1 regulators in other intracellular pathogens. Experimental Procedures Effector Library Screen A library of L. pneumophila Dot/Icm effectors was maintained as previously described (Barry et al., 2013) and adapted from (Losick et al., 2010). 4 ×...
STAT3 is an important regulatory factor for cell cycle regulators Tumor cells are distinguished by their unrestricted proliferation, closely linked to their uncontrolled cell cycle. The deregulation of cancer-related genes and proteins, such as STAT3, leads to abnormal cell cycle. Abnormal expression le...
The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remains elusive. Here, we have screened for regulators of PRKN-independent mitophagy using an siRNA library targeting 197 proteins containing lipid interacting d
Among them, we identified some genes related to lymph node metastasis in patients with pancreatic cancer: oncogenes, tumor suppressor genes, apoptosis and antiapoptosis genes, tumor angiogenesis factors, and cell cycle regulators. Genes promoting the growth of tumor cells were highly expressed in ...
hinting that NO may be converted in NO3−for this period. DEA-NONOate also exhibited a negative effect on the transcription ofNIT1used as a control gene (Fig.3a, insertion). These results are consistent with a balance of NO levels detected in cells and in culture broth (Fig.3b). The...
18.RA has been shown to act as a differentiating agent for both normal and transformed immature myeloid cells,19,20suggesting that thefusion proteinsmight antagonize normal RA-dependent differentiation. Conversely, overexpression of wild type (WT) RARα (as well as dominant negative forms of this ...
negative B-cell lines, those with the same G6PD isoenzyme as the Thus, although there is evidence that BCR-ABL1 can initiate a patient's own leukaemia showed multiple non-Ph cytogenetic myeloproliferative disease in experimental animals, there is abnormalities, whereas those with the non-leukaemia...