Hedgehogs as Negative Regulators of the Cell Cycle Extra View ND ES SCView, Extra
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Both positive and negative signals govern the progression of cells from G1 into S phase, and a variety of data implicate the E2F transcription factor as a ... DG Johnson,K ...
Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes in Arabidopsis. SNI1 binds to the activation domains of E2F transcription factors, the key regulators of cell cycle progression, and represses their ...
Adult human pancreatic β-cells are primarily quiescent (G0) yet the mechanisms controlling their quiescence are poorly understood. Here, we demonstrate, by immunofluorescence and confocal microscopy, abundant levels of the critical negative cell cycle regulators, p27(Kip1) and p18(Ink4c), 2 key ...
Objective To study the effect of Weikangning (WKN) containing serum on growth and cell cycle regulators of gastric cancer cell. 目的观察中药胃康宁含药血清对胃癌细胞生长与胃癌细胞周期调控因子CyclinD2、CyclinE、Cdk2(Cyclin dependant kinase2,CDK2)Cdk4、Cdk6和p16INK4a、p27KIP1mRNA及其蛋白表达的...
Furthermore, induction of activated K-down-regulated p27and up-regulated p53. Up-regulation of p53 was correlated with enhanced p53 transactivation and accompanied by up-regulation of p21and Gadd 45, two p53 effectors and negative cell cycle regulators. In addition, activated K-up-regulatesbut ...
STAT3 may exert its oncogenic effect by up-regulating transcription of genes involved in promoting growth and proliferation, but also by down-regulating expression of negative regulators of the same cellular processes, such as Necdin. 展开 关键词: metrology time scales relativity DOI: 10.1371/journal...
To identify the specific regulators involved, we performed Northern analyses on RNA extracted from human marrow LTC adherent layers, or stromal cell types derived from or related to those present in the adherent layer. These analyses showed marked increases in interleukin-1 beta (IL-1 beta), IL...
To identify the specific regulators involved, we performed Northern analyses on RNA extracted from human marrow LTC adherent layers, or stromal cell types derived from or related to those present in the adherent layer. These analyses showed marked increases in interleukin-1β (IL-1β), IL-6, ...
In hematopoietic malignancies, hypermethylation of genes, includingE-cadherin,DAP-kinase,and the cell-cycle regulatorsp15INK4Bandp16INK4A, has been established to be associated with gene inactivation.18, 19, 20, 21Based on methylation-associated transcriptional silencing ofSOCS-1in HCC and the import...