Negative regulators of cell cycle were significantly up-regulated in the Ezh2 SET domain depleted fetal livers.Hiroyuki KoikeRie OuchiYasuharu UenoSusumu NakataYuta ObanaKeisuke SekineYunWen ZhengTakanori TakebeKyoichi IsonoHaruhiko Koseki
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27 Kip1 negative cell cycle regulators,such as p18INK4C(p18),p27Kip1(p27)and MAD1,can regulate the self-renewal of HSCs.It is unknown whether the removal ......
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer developmentdoi:10.1038/s41388-018-0603-7Lung cancer is one of the major causes of cancer death and clarification of its molecular pathology is highly prioritized. The physiological importance of mRNA degradation through the ...
Cell Research | Vol 21 No 7 | July 2011 scriptional sites and ensures that the gene is turned off in an efficient and specific manner [32, 33]. Phosphorylation-related residues of XerR are essential for its repressor function In vivo and in vitro experiments indicated that XerR can ...
Mol. Cell. Biol., 22 (2002), pp. 309-320 View in ScopusGoogle Scholar Obara-Ishihara and Okayama, 1994 T. Obara-Ishihara, H. Okayama A B-type cyclin negatively regulates conjugation via interacting with cell cycle ‘start’ genes in fission yeast EMBO J., 13 (1994), pp. 1863-1872 ...
If CB1 receptors are key presynaptic regulators of synaptic transmission (including the excitatory transmitter glutamate), then one of their most prominent applications should be the control of excess presynaptic activity. Increased abundance of glutamate is a feature of traumatic insults causing neuronal ...
[27]. Prompted by our finding that NAC1 and BCL6 are co-transcriptional regulators, we investigated their expression patterns in a panel of ovarian cancer cell lines and HGSC specimens, using qPCR and immunohistochemistry respectively. We found that these two molecules were coordinately up-regulated...
Negative regulators of photomorphogenesis such as COP1, SHW1 and MYC2 act as positive regulators of lateral root formation without any effect on root length [39, 64, 65]. This study shows that in addition to lateral root formation, LeMYC2 also promotes the root length of tomato plants. The...
Class I DYRK kinases have diverse functions in cell proliferation and differentiation by regulating the degradation of key cell cycle regulators such as CYCLIN D1 and p27KIP1 via phosphorylation17,68. These kinases also modulate gene expression through direct effects on transcription factors and ...
To identify the specific regulators involved, we performed Northern analyses on RNA extracted from human marrow LTC adherent layers, or stromal cell types derived from or related to those present in the adherent layer. These analyses showed marked increases in interleukin-1β (IL-1β), IL-6, ...