BCL6-Dependent Negative Regulation of Cell Cycle Checkpoint Regulators Enables Drug-Resistance in Ph+ Acute Lymphoblastic Leukemia.765BCR-ABL1 tyrosine kinase inhibitors (TKI) are widely used for the treatment of patients with Ph+ ALL and CML. To elucidate mechanisms of TKI-resistance in Ph+ ALL...
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors plays an important role in controlling cell proliferation and differentiation. C... Johnson,F P. - 《Journal of Cell Science》 被引量:...
FcγRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3′-inositol phosph... kinase, Akt, provides an additional mechanism for FcγRIIb-mediated negative regulation of BCR-coupling to ErkMAPkinase, cell survival ...
Furthermore, induction of activated K-down-regulated p27and up-regulated p53. Up-regulation of p53 was correlated with enhanced p53 transactivation and accompanied by up-regulation of p21and Gadd 45, two p53 effectors and negative cell cycle regulators. In addition, activated K-up-regulatesbut ...
Negative regulation of G1/S transition by the candidate bladder tumour suppressor gene DBCCR1 A. ( 2001 ) Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1 . Oncogene 20 , 2956 – 2964 .Nishiyama H, Gill JH, Pitt E, Kennedy W, Knowles MA....
During studies on the influence of Fv-2 on the cycle state of the erythroid burst-forming unit (BFU-E), an activity was found in bone marrow supernatants from C57BL/6 (B6) mice that shut down DNA synthesis of the BFU-E in vitro. It acted within minutes, its action was completely rev...
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal neg
Since HePTP is preferentially expressed in T cells and may be involved in the regulation of cell proliferation, we decided to investigate the involvement of this enzyme in TCR-induced T cell activation. We report that HePTP had a strong inhibitory effect on the transcriptional activation of a ...
Nuclear receptor subfamily 4 group A member1 (NR4A1), an orphan nuclear receptor, is involved in the transcriptional regulation of thecal cell androgen bio... X Kai,Liu Jia-yin,BD Murphy,... - 《Molecular Endocrinology》 被引量: 17发表: 2012年 The orphan nuclear receptor estrogen-related ...
Yoshida, Y. et al. Negative regulation of BMP/Smad signaling by Tob in osteoblasts.Cell103, 1085–1097 (2000). ArticleCASPubMedGoogle Scholar Itoh, S., Itoh, F., Goumans, M.-J. & ten Dijke, P. Signaling of transforming growth factor-β family members through Smad proteins.Eur. J. ...