Alberts, A. S., and A. Schonthal. Positive and negative regulation of cell cycle progression by serine threonine protein phosphatases. In V. Hu (ed.), The cell cycle: regulators, targets, and clinical applications, in press. Plenum, New York....
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. UsingSirt1-deficient mice, we found thatSirt1andPeriod 2(Per2) constitute a reciprocal negative regulation loop that plays important ...
ARTICLE Received 19 May 2016 | Accepted 27 Jul 2016 | Published 7 Sep 2016 DOI: 10.1038/ncomms12730 OPEN NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation Meixiang Yang1,2,*, Shasha Chen1,*, Juan Du1, Junming He2, Yuande Wang2, Zehua...
The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine pathways, particularly the receptor-associated tyrosine kinase/signal transducer and activator of transcription (Jak/STAT) pathways of transcriptional activation. SOCS-1 (also ...
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however, a proportion of patients have missed the su
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with higher aggressiveness and poorer outcomes. Recently, long non-coding RNAs (lncRNAs) have become the crucial gene regulators in the progression of human cancers. However, the function
Recent studies in yeast, animals and plants have provided major breakthroughs in unraveling the molecular mechanism of higher-order gene regulation. In con... PF Fransz,JH de Jong - 《Current Opinion in Plant Biology》 被引量: 104发表: 2002年 Chromatin Structure and Dynamics: Meeting Review St...
Subsequent down regulation of CPS production during colonisation may lead to exposure of other bacterial cell surface structures required for the attachment and/or evasion of host immune response. Conclusions The results of this study demonstrated a complex interplay of Campylobacter capsule and ...
coding RNAs (ncRNAs) in the regulation of the IFN response is less well understood. Amongst the various classes of ncRNAs, micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most widely studied in biological processes including host–pathogen interactions5,6....
Upregulation of CD47 in human intestinal epithelium in UC and CD patients and in mouse intestinal epithelium during DSS-induced experimental colitis Full size image Full size image Inflammatory cytokines enhance intestinal epithelial cell CD47 expression ...