Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circ
Melanoma-associated antigen recognized by T cells (MART-1): the advent of a preferred immunocytochemical antibody for the diagnosis of metastatic malignant melanoma with fine-needle aspiration Cancer, 87 (1999), pp. 37-42 View in ScopusGoogle Scholar 34 PA Fetsch, FM Marincola, A Abati The new...
Naïve B16 specific Pmel-1 T cells are primed by tumor growth and infiltrate tumors after adoptive transfer into tumor bearing mice.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, Li
Adoptively transferred Pmel-1 T cells display lytic capability in the periphery after priming by tumor growth.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, LiFrancesca, AvogadriRicardo, ToledoCrow...
Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein...
The E3 ubiquitin ligase Casitas B-lineage lymphoma B (CBL-B) is highly expressed in T cells, where it functions as an intracellular checkpoint that constrains T-cell activation following T cell receptor (TCR) engagement, therefore limiting T cell-mediated antitumor responses. Methods We have ...
In Vivo Synergy of IL-21 Plus IL-2 in A Murine Transgenic pmel-1 Therapeutic Melanoma Tumor Model Results in Significant Anti-Tumor Immunity and Durable Long-Term Curative Effectdendritic cellsimmunotherapyserum-free mediumanti-interleukin-10
We investigated the function of MART-1 using a multidisciplinary approach, including the use of siRNA to inhibit MART-1 function and the use of transfection to re-express MART-1 in MART-1-negative cells. We show that MART-1 forms a complex with Pmel17 and affects its expression, stability...
Pmel-1 TCR tetramer staining distinguishes the gene dosage of pmel-1 transgene in CD8+ T cells.Yun JiNatalie AbramsWei ZhuEddie SalinasZhiya YuDouglas C. PalmerParthav JailwalaZulmarie FrancoRahul RoychoudhuriEric Stahlberg