Naïve B16 specific Pmel-1 T cells are primed by tumor growth and infiltrate tumors after adoptive transfer into tumor bearing mice.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, Li
To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells ...
AIM:To develop an effective assay for amplifying human T-cell receptor (TCR) variable region of β chain (Vβ)-encoding genes. 目的:建立一种高效扩增人T细胞受体(TCR)β链可变区(Vβ)基因的方法。 更多例句>> 4) TBX21 T细胞转录因子基因 1. we chose the T box expressed in T cells gene ...
//www.bjcancer.com gp100/pmel17 and tyrosinase encode multiple epitopes recognized by Th1-type CD4+T cells LS Kierstead1, E Ranieri1, W Olson1, V Brusic4, J Sidney5, A Sette5, YL Kasamon1, CL Slingluff Jr6, JM Kirkwood2,7 and WJ Storkus1,3,7 1Departments of Surgery, 2Medicine...
Six CTL clones recognized the Melan-A/MART1 antigen, whereas the remaining 40 CTL clones recognized a Pmel17/gp100 antigen. These 40 anti-PmelI7/gpl00 CTL clones were all able to lyse T2 cells pulsed with the antigenic peptide YLEPGPVTA, as previously reported. The T-cell receptor beta ...
andthefragmentwasclonedintopGL3-basicvector.The recombinantplasmidwastransfectedinto293TandA375cells,therelativeluciferaseactivitywas measuredbydualluciferaseassaysystem,andthetranscriptionfactorbindingsitesinthecore promoterregion werepredictedbybioinformatics.Thetranscriptionfactorbindingsitesonthe pGL3-327plasmidwere...
Note that the fragments reactive with antibodies to the RPT and PKD domains in the insoluble fractions of MNT-1 cells migrate with different molecular weights, indicating that these domains are proteolytically separated within Triton X-100-insoluble fibrils. C, MNT-1 melanoma cell homogenates (T ...
To analyze the specificity of αPEP25h for Pmel17, we used MNT-1 melanoma cells, which remain quite differentiated and highly pigmented (18, 38), and we compared its immunoreactivity patterns with those of αPEP13h. The processing of Pmel17 was assessed by [35S]Met/Cys metabolic labeling ...
Adoptively transferred Pmel-1 T cells display lytic capability in the periphery after priming by tumor growth.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, LiFrancesca, AvogadriRicardo, ToledoCrow...
In Vivo Synergy of IL-21 Plus IL-2 in A Murine Transgenic pmel-1 Therapeutic Melanoma Tumor Model Results in Significant Anti-Tumor Immunity and Durable Long-Term Curative Effectdendritic cellsimmunotherapyserum-free mediumanti-interleukin-10