Adoptively transferred Pmel-1 T cells display lytic capability in the periphery after priming by tumor growth.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, LiFrancesca, AvogadriRicardo, ToledoCrow...
【T细胞表位】:细胞表位指被T细胞受体(T-cell receptor /TCR)识别的抗原表位,表位成分为蛋白质降解后的多肽,多存在于抗原分子内部,需要经过抗原递呈细胞(antigen presenting cells /APC)加工后与MHC分子结合成为复合物才能被TCR识别。 【MHC】:主要组织相容性复合体,MHC可以分为经典MHC与非经典MHC两类,经典MHC包括MHC...
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抗体类型 IgG1 免疫原 Full-length protein expressed in 293T cell transfected with human SILV expression vector 实际分子量 70.3KD 成分 PBS (pH7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. 纯化方式 Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatogra...
AIM:To develop an effective assay for amplifying human T-cell receptor (TCR) variable region of β chain (Vβ)-encoding genes. 目的:建立一种高效扩增人T细胞受体(TCR)β链可变区(Vβ)基因的方法。 更多例句>> 4) TBX21 T细胞转录因子基因 1. we chose the T box expressed in T cells gene ...
Briefly, 5 × 106 cells were resuspended in 1 ml 10 mM Tris-HCl pH 7.4 containing protease inhibitor (Complete, Roche) and incubated for 10 min on ice. Lysed cells were Dounce homogenized with 30 strokes (“tight” pestle) and centrifuged at 800 g/4 °C/10 min. The...
(B) mRNA expression in B16-F0 and MNT-1 cells of BACE1, BACE2 and PMEL; normalized to GAPDH. Data is shown as mean ± SD. (C) PMEL17 processing analyses in B16-F0 treated cells with compounds of different selectivity to BACE1 and BACE2. PMEL17 full length as well as the ...
Finally, we show that in wild-type embryos-expressing cells are initially uniformly spread before forming aggregates and eventually blotches, as seen in the adults. In Terrazzo embryos, the aggregates fail to form. Our results provide insights into the mechanisms governing colouration patterning in ...
Flow cytometry assay demonstrated that G11B could bind to the surface of PMEL positive melanoma cells but not PMEL negative cells. Taken together, these results show that this G11B provides a useful tool for the antibody drug conjugate therapy study in some pigmentary diseases. 展开 年份: ...
Six CTL clones recognized the Melan-A/MART1 antigen, whereas the remaining 40 CTL clones recognized a Pmel17/gp100 antigen. These 40 anti-PmelI7/gpl00 CTL clones were all able to lyse T2 cells pulsed with the antigenic peptide YLEPGPVTA, as previously reported. The T-cell receptor beta ...