Naïve B16 specific Pmel-1 T cells are primed by tumor growth and infiltrate tumors after adoptive transfer into tumor bearing mice.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, LiF...
Pmel17与黑素小体的结构形成,分级组装,转运功能等密切相关,其表达受小眼相关转录因子、眼白化病1型因子、α黑素细胞刺激素等因素的调节。Pmel17参与了白癜风发病,为白癜风的免疫机制研究提供新的方向,Pmel17还可作为黑素瘤的治疗靶点。 关键词: 黑素细胞;白癜风;黑色素瘤;gp100黑色素瘤抗原;黑素小体;Pmel17 ...
//www.bjcancer.com gp100/pmel17 and tyrosinase encode multiple epitopes recognized by Th1-type CD4+T cells LS Kierstead1, E Ranieri1, W Olson1, V Brusic4, J Sidney5, A Sette5, YL Kasamon1, CL Slingluff Jr6, JM Kirkwood2,7 and WJ Storkus1,3,7 1Departments of Surgery, 2Medicine...
AIM:To develop an effective assay for amplifying human T-cell receptor (TCR) variable region of β chain (Vβ)-encoding genes. 目的:建立一种高效扩增人T细胞受体(TCR)β链可变区(Vβ)基因的方法。 更多例句>> 4) TBX21 T细胞转录因子基因 1. we chose the T box expressed in T cells gene ...
The antibody 31D1 also reacted uniformly with live cells by flow cytometry, but more weakly than 17A9, and was therefore not selected, as we have found this to correlate with cell killing by the conjugated antibody. Finally, antibody 14C10 appeared very similar to 17A9 and thus did not ...
Note that the fragments reactive with antibodies to the RPT and PKD domains in the insoluble fractions of MNT-1 cells migrate with different molecular weights, indicating that these domains are proteolytically separated within Triton X-100-insoluble fibrils. C, MNT-1 melanoma cell homogenates (T ...
Adoptively transferred Pmel-1 T cells display lytic capability in the periphery after priming by tumor growth.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, LiFrancesca, AvogadriRicardo, ToledoCrow...
In Vivo Synergy of IL-21 Plus IL-2 in A Murine Transgenic pmel-1 Therapeutic Melanoma Tumor Model Results in Significant Anti-Tumor Immunity and Durable Long-Term Curative Effectdendritic cellsimmunotherapyserum-free mediumanti-interleukin-10
2004. Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules. J. Immunol. 172: 2845-2852.Ramakrishna,V,Treml,JF,Vitale,L,Connolly,JE,O’Neill,T,Smith,PA,Jones,CL,He,LZ,Goldstein,...
Pmel-1 TCR tetramer staining distinguishes the gene dosage of pmel-1 transgene in CD8+ T cells.Yun JiNatalie AbramsWei ZhuEddie SalinasZhiya YuDouglas C. PalmerParthav JailwalaZulmarie FrancoRahul RoychoudhuriEric Stahlberg