通过相同表位特异性CD8 + T细胞的过继细胞转移(ACT),靶向黑素体蛋白或致癌CDK4R24C(细胞周期蛋白依赖性激酶4),揭示了多种遗传和非遗传免疫逃逸机制: 过继性T细胞疗法如靶向黑素体蛋白(TYRP1和RAB38)可促进黑色素瘤细胞去分化并增加髓样细胞浸润;如靶向CDK4R24C,不会促进细胞去分化,但是此靶点与免疫逃逸有着密切...
In both SKCM and SKCM-metastasis patients, PMEL expression is negatively correlated with the infiltration cells of CD8+ T cells, macrophages, and neutrophils. Programmed cell-death protein 1 just showed response rates ranging from 20% to 40% in patients with melanoma, so it is cr...
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo Int J Cancer, 66 (1996), pp. 470-476 View in ScopusGoogle Scholar 46 AF Kirkin, K Dzhandzhugazyan, J Zeut...
.com Keywords: tyrosinase; gp 100/pmel17; melanoma; helper T cells; ELISPOT; vaccine The recent understanding of the molecular basis of T cell recogni- tion of human tumours has allowed for the development of vaccine trials targeting the induction of antigen-specific, tumour-reactive CD8+ CTL....
The absence of PD-1 rendered mice resistant to viral infection and suppressed tumor growth and tumor metastasis by reducing the antigen-recognition threshold and increasing the cytotoxic activity of CD8+ T cells. PD-1/PD-L1 pathway-targeted therapies are under development in multiple diseases, ...
T cells by using a T cell receptor transgenic mouse (pmel-1) whose CD8(+) T cells recognize an epitope derived from the self/melanoma antigen gp100... CA Klebanoff,SE Finkelstein,DR Surman,... - 《Proc Natl Acad Sci U S A》 被引量: 1071发表: 2004年 MART-1 Is Required for the ...
Pmel-1 TCR tetramer staining distinguishes the gene dosage of pmel-1 transgene in CD8+ T cells.Yun JiNatalie AbramsWei ZhuEddie SalinasZhiya YuDouglas C. PalmerParthav JailwalaZulmarie FrancoRahul RoychoudhuriEric Stahlberg