Plasma cells in bone marrow — an artifactual change mimicking metastasisKotruM.SharmaS.AgarwalingentaconnectIndian Journal of Hematology & Blood Transfusion
Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow ...
The researchers monitored the survival of fluorescently labeled plasma cells in the spleen, bone marrow, and gut for over a year and found that the frequency of fluorescent plasma cells decreased to less than 60% within one month, and as low as 3%–20% within one year. The bone marrow app...
Thus, PD-L1 expression can be a useful prognosis predictor in NDMM patients, whereas ASCT may be used in patients with high PD-L1 expression. We developed a prognostic nomogram and found that a combination of PD-L1 expression in bone marrow plasma cells and clinical parameters (age, cyto...
BJBain, inBlood and Bone Marrow Pathology (Second Edition), 2011 Plasma cells There are less than 1–2% ofplasma cellsin normal BM. An increased percentage of BM plasma cells may be found in a wide range of pathologic conditions (Box 5.2). In various non-neoplastic conditions, up to 50%...
Related to Plasma cells:Macrophages,Histiocytes,Memory cells n. Any of various short-lived cells that develop from activated B cells and secrete large numbers of antibodies. They are found chiefly in the bone marrow, spleen, and lymph nodes. Also calledplasmacyte. ...
Myeloma plasma cells constitute 10% to 90% of the total bone marrow cell count in patients with multiple myeloma (MM). These cells express a variety of cell surface markers, such as HLA-ABC and HLA-DR, and surface antigens that are necessary for professional antigen-presenting cells, includi...
Bergsagel PL,Masellis Smith A,Belch AR et al.The blood B-cells and bone marrow plasma cells in patients with multiple myeloma share identical IgH rearrangements.Current Topics in Microbiology and Immunology. 1995Bergsagel PL,Masellis Smith A,Belch AR et al.The blood B-cells and bone marrow ...
in the serum and/or urine; at least 10% neoplastic plasma cells in the bone marrow or their presence in other tissue; and evidence of end-organ damage, related to the underlying plasma cell disorder, includinghypercalcemia(C), renal failure (R), anemia (A), andbone lesions(B), commonly...
PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other... R Yang,S Elsaadi,K Misund,... - 《Journal for Immunotherapy of Cancer》 被引量: 0发表: 2020年 Immunogenomic Landscape of Hematol...