Potassium channels constitute the largest and most ubiquitous and diverse ion channel family. They regulate several physiological processes including electrical signalling, hormone and neurotransmitter release, muscle contraction, cardiac function, cell proliferation and immune function, which are underscored by...
The Pharmacology of ATP-Sensitive Potassium Channels Annu Rev Pharmacol Toxicol. 1993;33:597-637. Research Support, Non-U.S. Gov't; Review G Edwards,AH Weston - 《Annual Review of Pharmacology & Toxicology》 被引量: 1296发表: 1993年 Potassium channels and pain: present realities and future ...
[6] Wulff, H., Castle, N. A., & Pardo, L. A. (2009). Voltage-gated potassium channels as therapeutic targets.Nature Reviews. Drug Discovery, 8(12), 982–1001. [7] Cheng, N., Ren, S., Yang, J.-F., Liu,...
G-protein-coupled inwardly rectifying potassium channels (GIRKs) are important for regulation of synaptic transmission and neuronal firing rates. Because o... JM Lewohl,WR Wilson,RD Mayfield,... - 《Nature Neuroscience》 被引量: 347发表: 1999年 The role of members of the pertussis toxin-sensi...
Physiology and Pharmacology of Two-Pore Domain Potassium Channels Searching the DNA database has led to the identification of a class of K+ channels now referred to as two-pore or tandem-pore domain K+ (K2P) channels. The... Donghee,Kim - 《Current Pharmaceutical Design》 被引量: 258发表...
Structure-activity studies on scorpion toxins that block potassium channels: A. L. Harvey,1H. Vatanpour,1E. G. Rowan,1C. Vita2 and M.-F. Martin-Eauclaire3 (1Department of Physiology and Pharmacology, Strathclyde University, Glasgow, U.K... The effect of temperature on phospholipase A2 ...
Apamin is a potent blocker of calcium-activated small conductance potassium (SK) channels in neurons, liver, skeletal muscle and ileum smooth muscle, but not in cardiac muscle. Cardiac muscle is devoid of SK channels; however, in isolated, single ventricular myocytes apamin is an extremely potent...
,钾通道开放药,potassium channel openers,【,降压机制,】,使激动剂引起的,IP,3,蓄积,细胞内储库,Ca,2+,释放,。,钾通道开放药,potassium channel openers,【,作用特点,】,主要作用于小动脉,外周阻力,;对静脉系统(容量血管)无明显影响。,1.,口服易吸收,肝代谢物仍具药理活性。,2.,用于轻、中度高血压。,3...
including: * Multidrug resistance and the "MDR"1 gene in gene therapy* Regulation of calcium channels in epithelial cells* Gene therapy and vascular disease* Potential therapeutic applications for Heparin * Calcium channel blockers* Antithrombotic agents* Regulation of potassium channels in epithelial ce...
Further, amitriptyline has an affinity for the Kv7 family of potassium channels, which are the targets of potential treatments of fibromyalgia [81,82]. Dopamine deficiency in the CNS has also been implicated in the pathophysiology of fibromyalgia, with a decrease in dopamine concentration leading to...