& Roux, B. Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature 431, 830–834 (2004). 10. Bostick, D. L. & Brooks, C. L. Selectivity in K þ channels is due to topological control of the permeant ion's coordinated state...
et al. Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility. Proc. Natl Acad. Sci. USA 108, 5443–5448 (2011). PubMed PubMed Central Google Scholar Mishra, V. et al. Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model...
Amiloride, a potassium-sparing diuretic, blocks ASIC1. It improved disability in both acute and chronic EAE models and a small open-label study in PPMS patients showed reduced brain atrophy and decreased changes of diffusion. A randomized phase IIclinical trialin progressive forms ofMSis being lau...
The structural similarity between the different cation channels means that selectivity is a serious issue; many sodium channel blockers also have effects on calcium channels (mexiletine and lifarizine), while others effect potassium channels (lidocaine). Selectivity over peripheral sodium channels is als...
项与Sodium channels x Potassium channel 相关的临床试验 Not yet recruiting临床2期IIT Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery (MINA) . New- onset postoperative atrial fibrillation (POAF) is a common complication after cardiac surg...
Currents Carried by Sodium and Potassium Ions through the Membrane of the Giant Axon of Loligo. J. Physiol. 1952, 116, 449–472. [Google Scholar] [CrossRef] Hille, B. Ion Channels of Excitable Membranes, 3rd ed.; Sinauer Associates Inc: Sunderland, MA, USA, 2001; ISBN 0878933220. [...
The databases were searched for both joint and separate instances of the keywords, e.g., “salt”, “salt intake reduction”, “sodium”, “sodium:potassium ratio”, “cereal products”, “food education”, “non-communicable diseases”, “hypertension”, “sodium sensitivity”, “food ...
Low sodium/high potassium diet for prevention of hypertension: probable mechanisms of action Clin Sci (Lond). 1980 Dec;59 Suppl 6:157s-160s. doi: 10.1042/cs059157s. 7004723 U.S.FDA - Daily Value on the New Nutrition and Supplement Facts Labels Ströhle A. [Sodium intake, blood pressure...
which regeneratively triggers the opening of more sodium channels, further depolarizing the membrane potential. Within milliseconds, the sodium channels transition to an ion-impermeable inactivated state, while potassium channels are activated. Both events contribute to the restoration of the resting membra...
Block of neonatal rat cortical sodium and potassium channels by DEET and related compounds.Daniel R. SwaleBaonan SunFan TongJeffrey R. Bloomquist