Ion channelsIon selectivityIonophoresPotassiumSodiumTransmembrane transportIn Nature, all biological systems present a high level of compartmentalization in order to carry out a wide variety of functions in a very specific way. Hence, they need ways to be connected with the environment for communication...
The sodium channels consist of a highly processed α subunit associated with auxiliary β subunits. The system (Na+–K+)-ATPase, which maintains high intracellular K+ and low intracellular Na+, is localized in the plasma membrane, and belongs to the family of P-type ATPases, can also be ...
The functioning of the cardiovascular system is critical for embryo survival. Cardiac contractions depend on the sequential activation of different classes of voltage-gated ion channels. Understanding the fundamental features of these interactions is important for identifying the mechanisms of pathologies deve...
Bezanilla, F., and Armstrong, C. M. (1972) Negative con-ductance caused by entry of sodium and cesium ions into the potassium channels of squid axons,J. Gen. Physiol.,60, 588–608. ArticlePubMedPubMed CentralCASGoogle Scholar Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., ...
In order for action potentials to traverse these very long distances in mammals, voltage-gated sodium (Na+) channels must be clustered at regularly spaced intervals along the axon. The mechanisms neurons use to regulate the kinds and locations of ion channels in a specific cell, and the ...
This discrimination is remarkable given the sub-angstrom difference in radius between sodium and potassium, and the fact that K þ channels can pass ions at up to diffusion-limited rates. This selection occurs within part of the ion channel pore known as the selectivity filter, which is ...
Potassium and sodium binding in the outer mouth of the K+ channel Biochemistry, 38 (1999), pp. 8599-8604 Google Scholar Heginbotham et al., 1999 L. Heginbotham, M. LeMasurier, L. Kolmakova-Partensky, C. Miller Single Streptomyces lividans K+ channels: functional asymmetries and sidedness...
Study of the separation of lactose, lactulose and galactose by liquid chromatography using cationic ion-exchange resin columns A strong acid cation-exchange resin, Dowex AG50W-X8 in potassium, calcium or sodium form, with water as eluent, has been used to separate three sugars (lac... K Dende...
Using computer simulations authors identify the dynamic molecular motions controlling the structural conformation of the TWIK1 ion channel, showing that its ability to transport sodium upon acidification result from the evolution of the classical potassium-selective pore. ...
(Kir) ion channels, termed ATP-sensitive inward rectifier potassium (KATP) channels, play a significant role in mediating the survival of both mammals and flies during a viral infection through modulation of antiviral RNA interference in the heart tissue [22,23,24]. Importantly, our previous ...