Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. J. Neurosci. 26, 4602–4612 (2006). CAS PubMed PubMed Central Google Scholar Storm, J. F. Action potential repolarization and a fast after-hyperpolarization in rat ...
这种效应来自BK(large conductance calcium-activated potassium channels),由于BK带来的强大钾离子同通透性,使得封闭钙离子的净效益是去极化。BK和Cav1.2、Cav2.2、Cav2.1都有空间上的共定位,这对其快速反应性可能有贡献。BK强烈地影响动作电位形状,因而长的动作电位(如Purkinje neurons)并不一定意味着高的钙离子内流。
Contribution of potassium channels to action potential repolarization of human embryonic stem cell‐derived cardiomyocytesBackground and purpose: The electrophysiological properties of hPSC-derived cardiomyocytes have not yet been characterized in a syncytial context. This study systematically characterized the ...
In this study, we explored the possibility that two-pore domain potassium (K2P) channels are sufficient to support action potential (AP) generation in the absence of conventional voltage-gated potassium (KV) channels. Hodgkin–Huxley parameters were used to mimic the presence of voltage-gated sodi...
These drugs also increase the effective refractory period (ERP) by delaying the reactivation of fast-sodium channels. Potassium-channel blockers delay the onset and prolong phase 3 repolarization, which lengthens the action potential duration and ERP....
The resting membrane potential is very negative during phase 4 (about -90 mV) because potassium channels are open (K+ conductance [gK] and K+ currents are high). As shown in the figure, phase 4 is associated with increased gK, which causes outward-directed K+ currents. In other words, ...
复合肌肉动作电位记录及在部分性运动传导阻滞诊断中的应用 www.ilib.cn 10. Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes 血小板活化因子对豚鼠心室肌细胞动作电位和钾通道的影响 www.ilib.cn 1 2 3您...
Often this term is used for channels that do not have high selectivity, and so are permeable to more than one cation. delayed rectifier Delayed rectifier is a term used to refer to the set of potassium conductances that repolarize the action potential. The term arises from the time-delayed...
Shaker-type Potassium Channels Drive the Action Potential Downstroke Modeling AWA Action Potentials Based on Known and Predicted Channels Natural Odor Stimuli May Elicit AWA Action Potentials AWA Action Potentials May Encode Specific Stimulus Features ...
Hyperpolarisation occurs principally due to potassium efflux before enough potassium channels can close, temporarily causing a greater negative-to-positive ion ratio between the inside and outside of the membrane. The membrane thus overshoots its resting potential, typically around − 90 mV, before ...