Dorsal root ganglia consist of small, nociceptive neurons and large proprioceptive neurons that transduce external sensory stimuli to the central nervous system through the firing of action potentials. Potassium channels can shape action potentials, set resting membrane potential and determine firing ...
et al. Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility. Proc. Natl Acad. Sci. USA 108, 5443–5448 (2011). PubMed PubMed Central Google Scholar Mishra, V. et al. Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model...
which creates a positive voltage potential[13]. After the membrane has reached a certain level of depolarization, potassium ions flux outward through their own channels, hyperpolarizing the membrane and thus returning the cell back to a resting potential in readiness for the cycle to resume[13,18...
We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent currents. 展开 关键词: cerebellum, potassium channels, sodium channel, spike trains, knock-out mice, Purkinje neurons ...
An important characteristic of excitable cells is their ability to repolarize rapidly after a depolarizing event such as a sodium action potential. This ability is caused by several fast potassium currents such as I A and I K (ref. 1) and possibly also a fast calcium-dependent potassium curren...
Although this chapter has focused on sodium channels, expression of other types of channels may also be altered in MS. Increased expression of Kv1.1 and Kv1.2 potassium channels (Wang et al., 1999), for example, has been reported along dysmyelinated axons within the brain of the Shiver...
comparing ion concentrations across the cell membrane, inside to outside, potassium measures about 40:1, and sodium, about 1:10. In nerve cells, the electrical charge across the cell membrane enables transmission of the nerve impulse—an action potential—when the charge is dissipated; sodium pla...
Action potential generation Sodium channels Structural biology This article is cited by Energy calculations for sodium vs. potassium on a prokaryotic voltage-gated sodium channel: a quantum-chemical study Juan Ferrer Emilio San-Fabián Theoretical Chemistry Accounts (2024) Structure of human NaV1.6 ...
Sodium channels x Potassium channel 盐酸维那卡兰 Kv1.5阻滞剂 在研机构 Aspen Pharmacare Holdings Ltd.[+8] 原研机构 Correvio Pharma Corp. 在研适应症 心房颤动[+1] 非在研适应症 房性心律失常[+1] 最高研发阶段批准上市 首次获批国家/地区 欧盟[+3]...
(salts: potassium, sodium, tartrate, ammonium sulfate, sodium acetate, lithium sulfate, sodium formate, sodium citrate, magnesium formate, sodium phosphate, potassium phosphage; organics: 2-propanol; non-volatile: 2-methyl-2,4-pentanediol); and • concentration of purified PNS SCP (e.g., 0.1...