Answer to: Fill in the blank: During the ___ phase of an action potential the sodium channels are inactivating and voltage-gated potassium...
The results agree with the time course of the permeability change to sodium ions calculated with the Hodgkin & Huxley equations.4. An average extra sodium influx of 7.13 p-mole/cm(2) per action potential was determined at 12 degrees C and of 5.23 p-mole/cm(2) per action potential at ...
Prolongation of Action Potential Duration and QT Interval During Epilepsy Linked to Increased Contribution of Neuronal Sodium Channels to Cardiac Late Na+ Current: Potential Mechanism for Sudden Death in Epilepsy... BN Smith - 《Epilepsy Currents》 被引量: 0发表: 2016年 Antiarrhythmic Effects of Ran...
We demonstrate that both species display a metabolic shift and an overall increased glycolytic gene signature in response to LPS treatment. The metabolic reprogramming is characterized by the upregulation of hexokinases in mouse microglia and phosphofructokinases in human microglia. This study provides a...
We conclude that the HCN4 encoded funny current If is active during a human SAN-like action potential waveform, with an amplitude that is strongly modulated by heart rate, β-adrenergic stimulation, and hyperpolarizing load of the atrium. The decrease of If at faster heart rates and its incre...
CDH (final concentration 10 mg ml–1) was digested in a reaction mix containing 140 ml per ml of the activated papain solution and 1 M sodium acetate (pH 5.0) at 25 °C for 4 h. The domains were separated from the residual intact CDH by column chromatography using a strong anion ...
Du et al reported transition-metal dyshomeostasis, particularly an excess of copper ions (Cu2+), has been identified as a critical factor in the pathogenesis of Alzheimer's disease (AD) [120]. Cu2+catalyzes the production ofROS, leading to neuroinflammation and neuronal cell apoptosis. This ...
It has been reported that alteration in the activities of different ATPases during stress might have broder biological effects such as alteration in the permeability property of nerve membrane to Ca2+ ions, the blockage of the membrane to the passage of Na2+ ions and inhibition of sodium-...
Following stringent high salt washes (50 mM Tris-HCl; 1 M NaCl; 1 mM EDTA; 1% NP-40; 0.1% SDS; 0.5% sodium deoxycholate), the immunoprecipitated RNA was 5′ end-labeled with radioactive 32Pγ-ATP62. The immunoprecipitated complexes were separated by SDS-PAGE and transferred to a...
Ni2 þ ions on the resin were removed by an amount of 100 ml of 50 mM EDTA in 1 M NaCl followed by equilibration with loading buffer for 15 min. To equip the IMAC column with Fe3 þ , 100 ml of 0.2 M FeCl3 was loaded into the column for another 15 min before sample Peptide...