The currents thus obtained nearly reproduced the original rectangular stimulus. Adding first 100 n M TTX and subsequently 100 n M TTX plus 10 m M TEA to the extracellular Ringer solution revealed the sodium and the potassium currents during an action potential. They were converted to ...
WE wish to report a new method with which we have been able to measure the sodium and potassium conductance changes postulated by Hodgkin and Huxley 1 in the course of a single action potential. To measure the membrane conductance at any desired time during the course of the action potential...
Arrhythmias associated with QT prolongation on the ECG often lead to sudden unexpected death in epilepsy. The mechanism causing a prolongation of the QT interval during epilepsy remains unknown. Based on observations showing an upregulation of neuronal sodium channels in the brain during epilepsy, we...
The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic
A gavage tube was used to deliver the substance by the oral route, which is the clinically expected route of administration of BM. The volume of administration was kept at 1 ml to the animal. 2.4. Induction of epilepsy Convulsions were induced by an intraperitoneal (i.p.) injection of ...
The succession of functional microorganisms has been used as an indicator to assess the ecological function and product maturity under the co-distribution of manure and crop residues, and can reflect the community distribution at the levels of the microbial family, genus, and phylum at different ...
Together with its activation as an inward depolarizing current at hyperpolarized potentials and its primary presence in the SAN, this explains that If is also named ‘pacemaker’ current (DiFrancesco, 1991). However, its biophysical properties also question the role of If in human SAN pacemaking ...
theDREBgene family is more diverse in barley than in wheat and rice. Further to this review, a convenient method for screening for salinity tolerance at germination is needed, and the mechanisms of action of the genes involved in salt tolerance need to be identified, validated, and transferred...
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following heterochronic parabiosis experiments, in which a young (3–4 months) and an aged (19 months) mouse share a common blood circulation. Our two datasets describe age- and rejuvenation-related ncRNA expression changes to reveal the potential of ncRNAs as targets for new pharmaceutical ...