However, there is a translational gap to the human situation where studies on human tissue are lacking. Voltage-gated sodium channels are essential for the generation of action potentials, and thus spontaneous
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
Interestingly, local application of phenytoin and carbamazepine has an antinociceptive effect that is more potent than that of lidocaine.42 It has been demonstrated that phenytoin, carbamazepine, and lamotrigine bind to a common recognition site on sodium channels, and it is probably the result of ...
It is hypothesized that the value given to education depends on individual socio-economic and political positions. This idea is reinforced by the analysis of the way students interviewed conceive other groups of students who chose other countries for higher education, as well as the way they see ...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a pr...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a pr...
the loss of interaction between α-subunits concurs with the loss of DN effect. Western is a representative example of four different experiments.dCo-immunoprecipation between truncated sodium channels illustrated in panel A and 14-3-3 were performed on total cell lysate (left) or plasma membrane...
R. Comparative actions of mexiletine on sodium channels in nerve, skeletal and cardiac muscle. Eur. J. Pharmacol. 74, 9–18 (1981). 44. Courtney, K. R. Quantifying antiarrhythmic drug blocking during action potentials in guinea-pig papillary muscle. J. Mol. Cell Cardiol. 15, 749–757 (...
Painful stimuli are detected by specialized neurons, nociceptors, and are translated into action potentials, that are conducted along afferent pathways into the central nervous system, where they are conceived as pain. Voltage-gated sodium channels (Na V
(C fibers). These channels mediate slowly activating and slowly inactivating sodium currents. The importance of some of these variants in nerve injury pain states is suggested by knock-down studies wherein reduction of, for example, Nav1.8 has no effect on baseline pain thresholds but reverses ...