Action potentials are physiological functions and passage of impermeable ions. The electrophysiological properties of these channels and their relationship with neurological and neuronal disorders have been identified. Subunit mutations are involved in the development of diseases, such as epilepsy, multiple ...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a pr...
Tetrodotoxin and Manganese Ion: Effects on Action Potential of the Frog Heart Tetrodotoxin, which effectively suppresses the permeability of various tissues to sodium ions, has no effect on the calcium action potential of the fiber of barnacle muscle, which potential is produced by increase in permea...
(C fibers). These channels mediate slowly activating and slowly inactivating sodium currents. The importance of some of these variants in nerve injury pain states is suggested by knock-down studies wherein reduction of, for example, Nav1.8 has no effect on baseline pain thresholds but reverses ...
aThis is done using harmonic interpolation, 这使用泛音插值法做,[translate] a,and described the roles of action potentials, calcium ions, sodiumions, neurotransmiters, and voltage-dependent ion channels. 和描述动作电位、钙离子、sodiumions、neurotransmiters和电压依赖离子渠道的角色。[translate]...
Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibers. J Physiol. 1951 Feb; 112 (3-4):496–508. [ PMC free article ] [ PubMed ]Huxley AF, Stampfli R (1951b) Effect of potassium and sodium on resting and action potentials of single myelina...
It is hypothesized that the value given to education depends on individual socio-economic and political positions. This idea is reinforced by the analysis of the way students interviewed conceive other groups of students who chose other countries for higher education, as well as the way they see ...
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function. Here, we elaborate on the recent finding that auxiliary subunits of voltage-gated sodium channels (β2 and β4) are BACE substrates. BACE1 produced ... T Huth,Karoline Schmidt-Neuenfeldt,A Rittger...
Mutation of these four cysteines to alanines had essentially the same effect on steady-state inactivation as 2-Br-palmitate treatment did on wt Nav1.5, and the Nav1.5-AAAA channels were insensitive to modulation by 2-Br-palmitate treatment (Fig. 7), indicating that one or more of these ...
The cysteine-rich amino-terminal domain of tenascin-R appears to be responsible for the repellent effect on β-subunit-expressing cells. Application of the cysteine-rich N-terminal domain of tenascin-R to channels expressed in Xenopus oocytes potentiates expressed sodium currents. The binding of...