N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury ...
The sodium channels consist of a highly processed α subunit associated with auxiliary β subunits. The system (Na+–K+)-ATPase, which maintains high intracellular K+ and low intracellular Na+, is localized in the plasma membrane, and belongs to the family of P-type ATPases, can also be ...
The functioning of the cardiovascular system is critical for embryo survival. Cardiac contractions depend on the sequential activation of different classes of voltage-gated ion channels. Understanding the fundamental features of these interactions is important for identifying the mechanisms of pathologies deve...
Lam, and Y. Jiang. 2013. Sodium and potassium competition in potassium-selective and non-selective channels. Nat. Commun. 4:2721. http://dx.doi.org/10.1038/ ncomms3721Sauer DB, Zeng W, Canty J, Lam Y, Jiang Y. Sodium and potassium competition in potassium-selective and non-selective ...
The influence of six intravenous induction agents (thiopentone, methohexitone, propanidid, Althesin, diazepam and ketamine) on plasma potassium, sodium and chloride concentrations was studied in 160 healthy female patients undergoing minor gynaecological operations. This investigation was limited to the...
Please try again and make sure cookies are enabledCited by (113) Molecular biology of insect sodium channels and pyrethroid resistance 2014, Insect Biochemistry and Molecular Biology Show abstract Use of venom peptides to probe ion channel structure and function 2010, Journal of Biological Chemistry ...
Bezanilla, F., and Armstrong, C. M. (1972) Negative con-ductance caused by entry of sodium and cesium ions into the potassium channels of squid axons,J. Gen. Physiol.,60, 588–608. ArticlePubMedPubMed CentralCASGoogle Scholar Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A.,...
We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent currents. 展开 关键词: cerebellum, potassium channels, sodium channel, spike trains, knock-out mice, Purkinje neurons ...
(e.g., voltage-gated calcium and sodium channels) consists of four homologous 6TM repeats. All these channel families are believed to be products of gene duplication events. Our results corroborate the idea that internal oligomerization (formation of tandem structures) of a channel was more ...
Twenty-two-year population trends in sodium and potassium consumption: the Minnesota Heart Survey. J Am Heart Assoc. 2013;2(5):e000478. View Article ... KA Meyer,LJ Harnack,RV Luepker,... - 《Journal of the American Heart Association》 被引量: 20发表: 2013年 Sodium in the Finnish die...