An overview of potassium channel activators for the treatment of overactive bladder: a survey of new structures 2000-2005. Exp Opin Ther Pat 16: 573-585.Argentirei TM , Butera JA ( 2006 ). An overview of potassium channel activators for the treatment of overactive bladder: a survey of ...
1 The K+ channel family is formed by a complex and diverse group of proteins that is known to exist in all three domains of organisms, eubacteria, archaebacteria, and eukaryotes, and this continues to stimulate discussions on ion channel evolution. K+ channels have a wide range of ...
An overview of hERG KCNH2 encodes hERG1, the α subunit of the delayed-rectifier potassium (Ikr) channel, and was first discovered as a homolog to the Drosophila Eag gene screened from a human hippocampus cDNA library by Warmke and Ganetzky in 1994. This subunit comprises 1159 amino aci...
the development ofM. xanthuswas inhibited in the presence of as low as 4 nM ambruticin VS-3 (Fig.1c), a polyketide that is known for its antifungal activity (Fig.1b)15. This observation, together with
In a previous article (Escande et al. 1988a), we have shown that cromakalim (BRL 34915), a potassium channel opener (PCO), is a potent activator of ATP-sensitive K + channels in cardiac cells. In the present article, the influence on K + channels of two other potassium channel opener...
Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis. 关键词: Renal medullary potassium channel diuretic drugs homeostasis ROMK 年份: 2018 ...
METHODS We studied two siblings showing prolonged QT intervals corrected for heart rate (QTc), their asymptomatic parents with only marginally prolonged QTc intervals and their family members. The potassium channel gene HERG was screened for mutations by deoxyribonucleic acid sequencing, and the electro...
Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action potential. The cycling of Navs through open, closed and inactivated states, and their closely c
Potassium channel blockers, including glibenclamide and tetraethylammonium, suppress the proliferation of endometrial cancer cells in a dose-dependent manner (Table 1) [98]. Amiodarone inhibits the invasion and migration of cancer cells by suppressing the expression of cadherin-11 and ERK 1/2 by...
Potassium Channel Openers The plasma membrane of airway smooth muscle has a high density of potassium channels. The opening of potassium ion channels in the cell membrane would allow potassium ions to move out from cells, an action normally maintained by the ion transporter potassium/sodium-ATPase....