MitochondriaFetal hypoxiaBIOGENESISEXPRESSIONPGC-1-ALPHAMETABOLISMSIRT3Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1 alpha (peroxisome proliferator-activated ...
Impaired function of mitochondria (the energy producing parts of cells) and the resulting oxidative stress contribute to Parkinson's disease, and may result from low levels of PGC-1alpha, a molecule that regulates mitochondrial biogenesis and antioxidant defenses. However, very high levels of PGC-1...
The uncontrolled cell proliferation is a remarkable feature of cancer and it is known to require a large amount of energy. PGC-1α/β were described as co activators capable of promoting mitochondria biogenesis and increase its respiratory function. Our hypothesis is that PGC-1α/β may be over...
CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their... GG Eduardo,RMM Efrén,CRE Margarita,... - 《Plos One》 被引量: 8发表: 2014年 Effect of thrombogenic and atherogenic diets on aspects of hepatic energy metabolism in ...
Mitochondria possess mito-ribosomes that in humans translate 13 different proteins of the respiratory chain. The majority of mitochondrial structure and biogenesis is dependent on the translation products of the cytosolic ribosomes19, thus mitochondrial biogenesis is at least partially dependent on ribosoma...
Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management 2017, Ageing Research Reviews Citation Excerpt : Furthermore, oxidation of cysteine residues of parkin in regions affected by parkin mutations in ...
Mitochondria are highly enriched in myocardial tissues and are especially crucial to the heart due to the high energy demands.17 In recent years, the irreplaceable role of mitochondrion in MIRI has been gradually discovering.18 AMPK is known as “cell energy receptor” and exists in the form of...
Mitochondria dysfunctionImpairment of mitochondrial biogenesis and mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD). However, the extent to which the impairment of mitochondrial biogenesis influences mitochondrial dysfunction at the onset and during progression of AD is still ...
When mitochondrial damage occurs, mitochondria are able to maintain a steady state of functioning through molecular and organellar quality control, thus ensuring neuronal function. And when mitochondrial quality control (MQC) fails, mitochondria mediate apoptosis. An apparently key molecule in MQC is the...
metabolic diseaseMitochondria play vital roles, including ATP generation, regulation of cellular metabolism, and cell survival. Mitochondria contain the majority of cellular nicotinamide adenine dinucleotide (NAD(+)), which an essential cofactor that regulates metabolic function. A decrease in both ...