Lingyun Zhu, et al. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients. Cell research 2010 摘要 PGC-1alpha是一种有效的转录辅激活因子,是心肌线粒体生物发生和活性的主要调节因子。...
In addition, the critical role of PGC-1伪 mediated mitochondrial biogenesis in cellular recovery was revealed: inhibition of PGC-1伪 using SR-18292 after EtOH removal significantly impeded recovery of mitochondrial damage, regeneration of neurites, and cell survival in a concentration-dependent manner...
To investigate the mechanism underlying the metabolic shift, a cDNA array analysis was performed and the gene identified with the highest reduction in RIP1 knockdown cells was PGC-1a, an important regulator of mitochondrial biogenesis and cell metabolism. The result was confirmed by RT-PCR and ...
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism and energy homeostasis. Inappropriate increases in PGC-1a activity have b...
PGC-1α helps to regulate cell processes important in adaptive thermogenesis and energy metabolism, including the related functions of glucose uptake, gluconeogenesis, insulin secretion, and mitochondrial biogenesis (3). Long thought to be a potential therapeutic target for the treatment of type II ...
PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism...
PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. 稀释比例 WB 1:500-1000. 背景说明 PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor...
//doi.org/10.1080/0886022X.2022.2126789 LABORATORY STUDY Activation of AMPK-PGC-1a pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis Jun WuÃ, Jushuang LiÃ, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang and Xiangyou Li Department ...
展开更多 This review focuses on PGC-1α-dependent signaling.Describing the effects of molecular mechanisms regulating mitochondrial biogenesis in skeletal muscles.It is important for treatment of patients with various metabolic disorders,as well as for optimization of training in...MORE 作者 张海鹏 马...
mitochondrial biogenesis through the GSK3b/PGC-1a pathway R Xu1, Q Hu2, Q Ma2, C Liu3 and G Wang*,1,2 Loss of the mitochondrial protease activity of Omi causes mitochondrial dysfunction, neurodegeneration with parkinsonian features and premature death in mnd2 (motor neuron degeneration 2) ...