Lingyun Zhu, et al. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients. Cell research 2010 摘要 PGC-1alpha是一种有效的转录辅激活因子,是心肌线粒体生物发生和活性的主要调节因子。...
In addition, the critical role of PGC-1伪 mediated mitochondrial biogenesis in cellular recovery was revealed: inhibition of PGC-1伪 using SR-18292 after EtOH removal significantly impeded recovery of mitochondrial damage, regeneration of neurites, and cell survival in a concentration-dependent manner...
Upon activation, PGC-1a promotes many, if not all of the adaptations of muscle to endurance training, including increased mitochondrial biogenesis and oxidative metabolism, vascularization and a switch towards type I and IIa oxidative, high-endurance muscle fibres22–24. Inversely, muscle-specific PGC...
PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism...
Now we investigated the role of mitochondrial dynamics (fission/fusion, biogenesis, mitophagy) in both degeneration and in recovery of neuronal cells. In neuronal PC12 cells, exposure to ethanol (EtOH) induced massive neurite loss along with widespread mitochondrial fragmentation, mitochondrial membrane ...
PGC1a is a transcriptional coactivator that promotes mitochondrial biogenesis, protects against oxidative stress and reprograms metabolism to influence drug sensitivity and survival. For example, a subset of melanomas is highly dependent on PGC1a and activates a powerful ROS detoxification capacity that ...
Previously in our laboratory we have explored the potential neuroprotective effects of the coactivator for the peroxisome proliferator゛ctivated receptor│(PPARγ), ㏄GC mainly involved in the regulation of metabolic processes and mitochondrial biogenesis. PGC has been shown to be involved in different...
Objective PGC-1a is an important mediator of mitochondrial biogenesis and function. We have previously shown that the AMP-activated protein kinase (AMPK) protects endothelial cells against oxidative stress by preservation of mitochondrial function in a PGC-1a dependent manner. Since dysfunctional ...
Overexpression of PGC-1α Increases Peroxisomal and Mitochondrial Fatty Acid Oxidation in Human Primary Myotubes Peroxisomes are indispensable organelles for lipid metabolism in humans and their biogenesis has been assumed to be under regulation by peroxisome prolifer... TY Huang,D Zheng,JA Houmard,....
2004. The estrogen-related receptor alpha (ERRa) functions in PPARg coactivator 1a (PGC-1a)-induced mitochondrial biogenesis. Proc Natl Acad Sci 101: 6472- 6477.Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, Oakeley EJ, and Kralli A. The estrogen-r...