MitochondriaFetal hypoxiaBIOGENESISEXPRESSIONPGC-1-ALPHAMETABOLISMSIRT3Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1 alpha (peroxisome proliferator-activated ...
PGC-1α is localized in both mitochondria (porin, red) and nuclei (DAPI, blue) (N). (TIF 2 MB) 40478_2014_170_MOESM4_ESM.tif Additional file 4: Figure S2.: Western blot analysis shows that U373 astrocyte-like cells treated with Prx3 and Trx2 containing lentiviral constructs have ...
Mitochondria are critical for cellular bioenergetics, and they mediate apoptosis within cells. We used whole body peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) knockout (KO) animals to investigate its role on organelle function, apoptotic signaling, and cytochrome-c ox...
Mitochondria possess mito-ribosomes that in humans translate 13 different proteins of the respiratory chain. The majority of mitochondrial structure and biogenesis is dependent on the translation products of the cytosolic ribosomes19, thus mitochondrial biogenesis is at least partially dependent on ribosoma...
摘要: EWS (Ewing sarcoma) encodes an RNA/ssDNA binding p 关键词:EWS PGC-1alpha protein stability mitochondria homeostasis energy metabolism 被引量: 14 年份: 2015 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 ResearchGate (全网免费下载) pnas.org (全网免费下载) ...
Mitochondria are highly enriched in myocardial tissues and are especially crucial to the heart due to the high energy demands.17 In recent years, the irreplaceable role of mitochondrion in MIRI has been gradually discovering.18 AMPK is known as “cell energy receptor” and exists in the form of...
Mitochondria carry out many of the processes implicated in maintaining axon health or causing axon degeneration, including ATP and reactive oxygen species ... O'Donnell,C Kelley,Vargas,... - 《Journal of Neuroscience》 被引量: 73发表: 2013年 Stochastic specification of primordial germ cells from...
MitochondriaCell LineCalciumInsulin ResistanceInsulinGlucoseAdiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane topology with the amino terminus located intracellularly, which is the opposite of G-protein-coupled receptors. Here we provide evidence that adiponectin induces ...
When mitochondrial damage occurs, mitochondria are able to maintain a steady state of functioning through molecular and organellar quality control, thus ensuring neuronal function. And when mitochondrial quality control (MQC) fails, mitochondria mediate apoptosis. An apparently key molecule in MQC is the...
Over-expression of the mitochondrial biogenesis regulator PPAR-纬 cofactor-1 alpha (PGC-1伪) in control RTPC increased basal and uncoupled cellular respiration, ATP, and mitochondria. Increasing mitochondrial number/function prior to oxidant exposure did not preserve mitochondrial function, but potentiated...