Mitochondrial quality controlSignaling pathwayNeurodegenerative diseasesNeuroprotective effectsAs one of the major cell organelles responsible for ATP production, it is important that neurons maintain mitochondria with structural and functional integrity; this is especially true for neurons with high metabolic ...
CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their... GG Eduardo,RMM Efrén,CRE Margarita,... - 《Plos One》 被引量: 8发表: 2014年 The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism ...
The uncontrolled cell proliferation is a remarkable feature of cancer and it is known to require a large amount of energy. PGC-1α/β were described as co activators capable of promoting mitochondria biogenesis and increase its respiratory function. Our hypothesis is that PGC-1α/β may be over...
Impaired function of mitochondria (the energy producing parts of cells) and the resulting oxidative stress contribute to Parkinson's disease, and may result from low levels of PGC-1alpha, a molecule that regulates mitochondrial biogenesis and antioxidant defenses. However, very high levels of PGC-1...
A very tangible consequence of this relationship emerges from our examination of this pathway during exercise under physiological and disease conditions. Physical exercise requires energy sources in the form of ATP mostly derived from mitochondria. Physical exercise is an established inducer of PGC-1α ...
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane topology with the amino terminus located intracellularly, which is t... M Iwabu,T Yamauchi,M Okada-Iwabu,... - 《Na...
PGC-1&945NAD(+)SIRTsmetabolic diseaseMitochondria play vital roles, including ATP generation, regulation of cellular metabolism, and cell survival. Mitochondria contain the majority of cellular nicotinamide adenine dinucleotide (NAD(+)), which an essential cofactor that regulates metabolic function. A ...
Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredoxin-2, which are involved in limiting ROS-induced damage. In this study, we explored the distribution and role of the mitochondrial antioxidants peroxiredoxin-3 and thioredoxin-2 as well as their ...
Mitochondria dysfunctionImpairment of mitochondrial biogenesis and mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD). However, the extent to which the impairment of mitochondrial biogenesis influences mitochondrial dysfunction at the onset and during progression of AD is still ...
MitochondriaFetal hypoxiaBIOGENESISEXPRESSIONPGC-1-ALPHAMETABOLISMSIRT3Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1 alpha (peroxisome proliferator-activated ...