We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitochondrial master regulator, PGC1α. We further show that a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression ...
mitochondrial biogenesisPGC-1αsilicaSilicosis is an incurable chronic fibrotic lung disease caused by long-term exposure to respirable silica particles. It is characterized by persistent inflammation and progressive fibrosis of lung tissues, which eventually leads to respiratory failure and seriously affects...
PGC-1alpha is suggested to play a pivotal role in the control of genetic pathways that result in homeostatic glucose utilisation in liver and muscle, beta cell insulin secretion and mitochondrial biogenesis. This review focuses on the role of PGC-1alpha in glucose metabolism and considers how ...
PGC-1α regulates the transcription of a broad array of genes and is a key player in mitochondrial biogenesis, consequently it is conceivable that the protective effects of enhanced PGC-1α levels extend beyond increased mitochondrial antioxidant production [24]. Since PGC-1α has such widespread ...
It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the ...
(NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis,and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure,regulating cellular cholesterol homoeostasis,and ...
Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways. Gureev AP, Shaforostova EA, Popov VN. Front Genet. 2019 May 14;10:435. doi: 10.3389/fgene.2019.00435. ...
Mitochondrial Metabolism Mitochondrial Biogenesis Metabolism Pathways and Processes Metabolic signaling pathways Nucleotide metabolism Molecular processes Mitochondrial transcription Metabolism Pathways and Processes Metabolic signaling pathways Lipid and lipoprotein metabolism Fatty acids Metabolism Typ...
(NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, ...
(NRFs).It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis,and is a major factor that regulates muscle fiber type determination.This protein may be also involved in controlling blood pressure,regulating cellular cholesterol homoeostasis,and the ...