However, the extent to which the impairment of mitochondrial biogenesis influences mitochondrial dysfunction at the onset and during progression of AD is still unclear. Our study demonstrated that the protein expression pattern of the transcription factor pCREB/CREB, together with the protein expression ...
(NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis,and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure,regulating cellular cholesterol homoeostasis,and ...
It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the ...
cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs).It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis,and is a major factor that regulates muscle fiber type determination (2).PPARGC1A may be also involved ...
(NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, ...
The coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) coordinates a broad set of transcriptional programs that regulate the response of skeletal muscle to exercise. However, the complete transcriptional network controlled by PGC-1 has not been described. In this study, ...
has emerged as a master regulator of mitochondrial biogenesis; furthermore, it has been shown that PGC-1alpha gene expression is induced by exercise and ... S Jager,C Handschin,J St.-Pierre,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量...
Impaired function of mitochondria (the energy producing parts of cells) and the resulting oxidative stress contribute to Parkinson's disease, and may result from low levels of PGC-1alpha, a molecule that regulates mitochondrial biogenesis and antioxidant defenses. However, very high levels of PGC-1...
PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α
By contrast, the transcriptional coactivator PGC-1α, which has roles in the regulation of mitochondrial biogenesis and reactive-oxygen-species detoxification, abrogated aSyn toxicity in both the axon and the cell body. The rapid onset of axonal pathology in this system, and the relatively moderate...