mitochondrial biogenesis (mb)中文 线粒体生物发生(mitochondrial biogenesis,简称MB)是指细胞从已有的线粒体增加其数量或提高其功能的过程。这一过程涉及到线粒体的生长、复制和分裂,以及线粒体DNA(mtDNA)的复制和转录。 在分子水平上,线粒体生物发生受到多种转录因子和信号通路的调控,如PGC-1α、NRF-1、NRF-2...
83The process of mitochondrial biogenesis is modulated by many transcriptional regulators present in the cell. Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1-alpha (PGC-1α), a cotranscriptional regulation factor is the key regulator of mitochondrial biogenesis which interacts with ...
Recent work has identified several stress-regulated pathways that affect mitochondrial biogenesis through modulation of the activity of PGC-1 alpha. This review focuses on caloric restriction, hypoxia as well as the role of reactive oxygen species in regulating mitochondrial biogenesis and how this ...
Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative disorders. PGC1α exerts its neuroprotective effects by promoting mitochondrial biogenesis (MB) and functioning. However, the precise regulatory role of PGC1α in the ...
Optimal mitochondrial biogenesis and OXPHOS seem also to be required for metastatic dissemination, as demonstrated upon silencing of the master regulator PPARG coactivator 1 alpha (PPARGC1A, best known as PGC-1α) in models of breast cancer146, and upon silencing of family with sequence similarity...
(MSCs) to the primary tumour site where they stimulate mitochondrial biogenesis in the MSCs through upregulation of PGC1a. Mitochondria are transferred to the melanoma cells via direct contact with the MSCs. Moreover, inhibition of MSC-derived PGC1a was able to prevent mitochondrial transfer and ...
Recently we have reported that mitochondria are transferred from BM stromal cells (BMSC) to AML blasts through tunnelling nanotubes (TNTs), a process which supports leukemic proliferation in-vitro and in-vivo. Moreover, we showed that tumor derived NOX2 generates superoxide......
Cellular and molecular neurobiologyMa L, Niu W, Lv J, Jia J, Zhu M, Yang S. PGC-1alpha-mediated mito- chondrial biogenesis is involved in cannabinoid receptor 2 agonist AM1241-induced microglial phenotype amelioration. Cell Mol Neurobiol. 2018;12(10):018-0628....
Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate. Clinical analysis of human invasive breast cancers ...
Regulation of PGC-1α on mitochondrial biogenesis of vascular endothelial cells in hyperglycemia Objctive To investigate the effect of peroxisome proliferator activated receptor gama coactivator 1 alpha(PGC-1α) on mitochondrial biogenesis of endotheli... SJ Chen,LV Ling-Bo,GC Luo,... - 《Shandong...