However, the extent to which the impairment of mitochondrial biogenesis influences mitochondrial dysfunction at the onset and during progression of AD is still unclear. Our study demonstrated that the protein expression pattern of the transcription factor pCREB/CREB, together with the protein expression ...
PGC-1α regulates the transcription of a broad array of genes and is a key player in mitochondrial biogenesis, consequently it is conceivable that the protective effects of enhanced PGC-1α levels extend beyond increased mitochondrial antioxidant production [24]. Since PGC-1α has such widespread ...
PGC1 alpha (peroxisome proliferator-activated receptor gamma co-activator 1 alpha) is the master regulator of mitochondrial biogenesis. We investigated the effects of hypoxia on PGC1 alpha expression following exposure at different gestational ages. Time-mated pregnant guinea pigs were exposed to ...
Bellner, "PGC-1 alpha regulates HO-1 expression, mito- chondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid," Prostaglandins & Other Lipid Mediators, vol. 125, pp. 8-18, 2016.Singh S P,Schragenheim J,Cao J,et al.PGC-1 alpha regulates HO-1 expression,mitochondrial dynamics...
Obrietan, KHoyt, K. R
Cellular biology IL-15 Signaling in Skeletal Muscle| Implications in Modulation of PGC-1alpha and Mitochondrial Biogenesis WEST VIRGINIA UNIVERSITY Emidio E. Pistilli O'ConnellGrant CAltering interleukin-15 (IL-15) signaling through ablation of interleukin receptor alpha (IL-15Rα) in the IL-15Rα...
These phosphorylations interfere with the ability of PGC-1α to bind to HNF4α, a transcription factor required for gluconeogenesis, while leaving undisturbed the interactions of PGC-1α with ERRα and PPARα, factors important for mitochondrial biogenesis and fatty acid oxidation....
Molecular Genetics and Genomics - The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protein in mitochondrial biogenesis,... 展开 关键词: PGC-1 alpha Mitochondrial biogenesis Skeletal muscle Adipose tissue Mitochondria ACTIVATED PROTEIN-KINASE COACTI...
In conclusion, these data suggest that mild HS is sufficient to induce mitochondrial biogenesis associated with activation of the AMPK-SIRT1-PGC-1alpha pathway in C2C12 myotubes. Therefore, it is possible that muscle heat production during exercise plays a role in mitochondrial biogenesis.ChienTing ...
Muscle platicity and gene regulation/expression:p38 gamma MAPK is required for exercise-induced PGC-1alpha expression and mitochondrial biogenesis in skeletal muscle[J].Federation of America Societies for Experimental Biology Journal,2008,(03):754-718....