Mitochondria are particularly sensitive to CDDP-induced damage. Cisplatin forms platinum (Pt)-DNA cross-links that destroy the structure of DNA, thus interfering with normal DNA transcription and replication mechanisms. [ 8 , 9 , 10 ] DNA damage, which is considered to play a core role in cel...
Mitochondria themselves, and in particular mitochondrial DNA (mtDNA), are susceptible to ROS, which may be regu- lated by peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and are vulnerable to oxidative dam- age[4]. Growing evidence has indicated that diabetes impairs ...
PGC-1 alpha Downregulation in Steatotic Liver Enhances Ischemia-Reperfusion Injury and Impairs Ischemic Preconditioningmitochondriaoxidative metabolismantioxidantsoxidative stressreactive oxygen speciesAims: Liver steatosis is associated with mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels ...
PGC-1α is a favored protein, which not only regulates muscle fiber type, inhibits muscle atrophy, but also participates in browning of white adipose tissue (WAT) and regulates body heat
Mitochondria are particularly sensitive to CDDP-induced damage. Cisplatin forms platinum (Pt)-DNA cross-links that destroy the structure of DNA, thus interfering with normal DNA transcription and replication mechanisms. [ 8 , 9 , 10 ] DNA damage, which is considered to play a core role in cel...
PGC-1α is also shown to regulate mitochondrial membrane structure and function by metabolic and membrane structural programs in the heart [14]. An important component of mitochondrial membranes is Cardiolipin (CL), which is exclusively synthesized in mitochondria [15]. CL plays an essential role ...
2M). Electron microscopy examination also confirmed the loss of mitochondria integrity in RTECs of adenine-fed and UUO mice. However, these were significantly improved by metformin (Fig. 3J and Supplementary Fig. 4F). These findings suggest that PGC-1α restores the impaired dynamics, morphology,...
(microtubule-associated protein 1 light chain 3 alpha) to promote selective degradation.3 An impairment of these processes has been implicated in aging, neurodegeneration and muscular atrophy.4 Skeletal muscle represents an interesting environment, as the plasticity of mitochondria is a key factor in ...
research on PGC-1α has energized the entire mitochondria field and has increased the chances that strategies to turbocharge mitochondrial activity may one day translate into therapies not only for metabolic disease, but perhaps also for certain cardiac problems and neurodegenerative diseases (Figure 1...
3i and j). Collectively these experiments show that PGC-1α driven mitochondrial biogenesis supports tumour growth. Mitochondrial transfer from MSCs to melanoma cells Next, we labelled MSC-derived mitochondria with mito9 virus (mCherry) and the A375 melanoma cells labelled with GFP membrane tag to...