Mitochondria damage in ambient particulate matter induced cardiotoxicity: Roles of PPAR alpha/PGC-1 alpha signalingCardiotoxicityMitochondria damagePPAR alphaParticulate matterParticulate matter (PM) had been associated with cardiotoxicity, while the mechanism of toxicity has yet to be elucidated, with ...
Inhibitors of Creb-Pgc1 alpha pathway significantly blocked the localization of Rab32 into LDs and MT, and significantly reduced FA-induced LDs lipolysis by targeting Atgl and Plin5. Meanwhile, the FA-enhanced LDs accumulation, and mitochondria! biogenesis, fusion and oxidation were also ...