Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, ...
This molecule can be regarded as an integrated drug delivery system, so it is called a molecular drug delivery system. In the context of cancer therapy, a peptide–drug conjugate comprises a tumor-targeting peptide, a payload, and a linker. Tumor-targeting peptides specifically identify membrane...
Accelerated killing of cancer cells using a multifunctional single-walled carbon nanotube-based system for targeted drug delivery in combination with photo... Accelerated killing of cancer cells using a multifunctional single-walled car- bon nanotube-based system for targeted drug delivery in combination...
Self-assembling peptides: implications for patenting in drug delivery and tissue engineering. In this paper, a comprehensive review of recent patents concerning the molecular self-assembly of peptides, peptide amphiphiles and peptidomimetics into mo... Pradeep,Kumar,Viness,... - 《Recent Patents on...
In this review, we will focus on drug delivery systems that have been engineered from protein materials, including silk, albumin, keratin, collagen, gelatin, elastin, and resilin (Fig. 1). We will discuss the guiding principles for the design of peptide- and protein-based delivery systems and...
plasmid DNA as the cargo therapeutic. Moreover, we also demonstrated measurable physiological changes and achieved beneficial therapeutic effects in preclinical murine models. The current work represents a large step towards clinical application of nucleic acid therapies, using peptide-based drug delivery ...
Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor...
2011). This 'lipid anchoring technique' allowing for subcellular drug delivery by drug conjugation to a lipid via a linker, was recently used to effec- tively inhibit the action of endosomal β-secretase (Rajendran et al. 2008a, b). β-Secretase inhibitors may be useful for the treatment...
Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often specifically termed as “the Trojan horse approach”, has become the “holy grail” in achieving effective delivery of macromolecular compounds such as proteins, DNA, siRNAs, and drug carriers. It is characterized by th...
Peptide-based supramolecular hydrogels have shown great promise as drug delivery systems (DDSs) because of their excellent biocompatibility, biodegradability, biological function, synthetic feasibility, and responsiveness to external stimuli. Self-assembling peptide molecules are able rationally designed into spe...