Due to this nature, most peptide and protein pharmaceuticals are delivered by invasive routes such as subcutaneous injections, often leading to the poor patient compliance. Alternatively, oral drug delivery offers painless (noninvasive), self-administrable, inexpensive, and convenient usage and thus ...
Peptide delivery Protein delivery Associated content An easily swallowed capsule injects drugs straight into the gut NatureResearch Highlight08 Sept 2021 Nature Biotechnology(Nat Biotechnol) ISSN1546-1696(online) ISSN1087-0156(print) Sign up for theNature Briefing: Translational Researchnewsletter — top...
M. Materials and methods for delivery of biological drugs. Nat. Chem. 8, 997–1007 (2016). CAS Google Scholar Antosova, Z., Mackova, M., Kral, V. & Macek, T. Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol. 27, 628–635 (2009). CAS Google ...
Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border. We h
Development and in vitro evaluation of polar lipid based lipospheres for oral delivery of peptide drugs. Int J Drug Deliv 2009; 1: 15 - 26.M. Singh, D. Singh, and S. Saraf, "Development and in vitro evaluation of polar lipid based lipospheres for oral delivery of peptide drugs," ...
This review summarizes the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs. Graphical abstract The current strategies for improving oral absorption of proteins and peptides (PPs) include ...
Merck licenses Cyprumed's oral drug delivery platform in $493M deal to develop oral peptide formulations, potentially for GLP-1 drugs.
formulated protein or peptide drugs may be administered by the oral route with retention of sufficient biological activity for their therapeutic use. Strategies for oral delivery Formulating for delivery through the gastrointestinal (GI) tract requires a multitude of strategies. The ...
There are comments on PubPeer for publication: Oral Delivery of Peptide Drugs Using Nanoparticles Self-Assembled by Poly(γ-glutamic acid) and a Chitosan Derivative Functionalized by Trimethylation (2008)
Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low permeability across the intestinal epithelium. Accordingly, the large numbers of biologic drugs that have become ...