Protein/Peptide Drug Delivery Systems: Practical Considerations in Pharmaceutical Product Development - ScienceDirectPran Kishore DebOmar Al-AttraqchiBalakumar ChandrasekaranAnant ParadkarRakesh K. TekadeBasic Fundamentals of Drug Delivery
At present, there is no one-size-fits-all strategy to maintain protein and peptide bioactivity through delivery system preparation, storage, and in vivo release. Instead, the selection of processes, materials, and storage conditions are dependent on the properties of the specific protein or peptide...
oral drug deliveryproteins and peptidesTherapeutic proteins and peptides hold great potential in treating metabolic disorders, infectious diseases, and cancers; however, their oral administration remains challenging due to enzymatic degradation and poor intestinal permeability. To address these limitations, ...
the barriers to protein drug delivery by the oral route. Routes of administration The most common route of administration for proteins and peptides is by injection, although many other routes have been tried with varying degrees of success (1). Routes such as intranasal ...
Panchagnula, Peroral Route: An Opportunity for Protein and Peptide Drug Delivery, Chem. Rev. 101 (2001) 3275-3303.Peroral Route:? An Opportunity for Protein and Peptide Drug Delivery. Anurag Sood,Ramesh Panchagnula. Chemical Reviews . 2001...
Once engineered, intracellular bacteria can efficiently deliver proteins to tumors. Current delivery methods, including nanoparticles, cell-penetrating peptides, and antibody drug conjugates have limited efficacy because of (1) poor uptake into cells, (2) lack of specificity to cancer cells, (3) degr...
delivery system, which can take the form of a scaffold (e.g., hydrogels and electrospun fibers), carrier (viral and nonviral), nano- and microparticle, or genetically modified cell. In this review, we will discuss the history and current technologies of drug, protein, and gene delivery in...
Protein– and peptide–drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Recent advancements in the proteomics and recombinant DNA technology, by enabling identification of distinct structural features of...
Susceptibility of proteins and peptides to proteases and other factors in the body renders their administration cumbersome. A novel drug-delivery system formulated using nanobiomaterials offers increased protection of the protein in the physiological system until it reaches the site of action and is ...
IgG-DTAF exhibits two relatively short (0.20 and 14.3 ns) rotational correlation times. The longer one, 14.3 ns, is in the range (14-18 ns) of the short phi which has been ascribed to the V-module flexing at switch peptides in the Fab segment. The four amino termini which exists at...