Indeed, even these molecules are targeted to the cells with the use of cell-penetrating peptides. In this review, delivery of the peptide and protein therapeutics using oral, transdermal and other routes is discussed in detail.doi:10.2174/1381612825666190206211458Thotakura, NagaraniKaushik, LokeshKumar, VipinPreet, SimranBabu, ...
The unique environmental conditions that a biologic experiences while being formulated in, or released from, a drug delivery system can present a substantial problem for retaining bioactivity through in vivo residence and release. Therefore, understanding the mechanisms of peptide and protein degradation,...
Susceptibility of proteins and peptides to proteases and other factors in the body renders their administration cumbersome. A novel drug-delivery system formulated using nanobiomaterials offers increased protection of the protein in the physiological system until it reaches the site of action and is ...
protein and peptide drugs A variety of strategies can be used to overcome the barriers to protein/ peptide drug delivery by the oral route. Dr Richard Soltero and Dr Nnochiri Ekwuribe, Nobex Corporation T he use of polypeptides and proteins for ...
Panchagnula, Peroral route: an opportunity for protein and peptide drug delivery, Chem. Rev. 101 (2001) 3275-3303.Sood A.and Panchagnula R, Parenteral Route: An Opportunity for Protein and Peptide Drug Delivery, Chemical Reviews, 101, pg no: 275-303, 2000....
Proteins and peptides have a great potential as therapeutic agents; they have higher efficiency and lower toxicity, compared to chemical drugs. However, th
synthetic peptide binder containing a single ASGPR ligand can promote degradation and induce enhanced functional consequences. To test this hypothesis, we used a targeting ligand composed of a polyspecific integrin-binding peptide (PIP), also known as EETI 2.5F, that was previously engineered to bind...
Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS. Here we identify a cell-permeable peptide, dNP2,...
delivery system, which can take the form of a scaffold (e.g., hydrogels and electrospun fibers), carrier (viral and nonviral), nano- and microparticle, or genetically modified cell. In this review, we will discuss the history and current technologies of drug, protein, and gene delivery in...
Cell-Delivery Embodiment The preferred biologically active substance to be delivered to a cell is a protein or peptide drug or an enzyme. In a particularly preferred embodiment, the active substance is a cell toxin to be delivered to selected cells. Such toxins include the pokeweed antiviral prot...