Giralt. Amphipathic peptides and drug delivery. Biopolymers 76 :196–203 (2004).FernandezCarneado, J., Kogan, M. J., Pujals, S. & Giralt, E. Amphipathic peptides and drug delivery. Biopolymers 76, 196-203 (2004).Fernandez-Carneado J, Kogan MJ, Pujals S, Giralt E. Amphipathic ...
Brain delivery of drug and MRI contrast agent: detection and quantitative determination of brain deposition of CPT-Glu using LC-MS/MS and Gd-DTPA using magnetic resonance imaging. Mol Pharm. 2016;13:379–90. Article CAS PubMed PubMed Central Google Scholar Takasato Y, Rapoport SI, Smith QR...
Peptides are small biological molecules that are attractive in drug delivery and materials engineering for applications including therapeutics, molecular building blocks and cell-targeting ligands. Peptides are small but can possess complexity and functionality as larger proteins. Due to their intrinsic pro...
evidence to the use of proteins such as monoclonal antibodies (MAbs), bispecific antibodies (BsAbs), Affibody molecules, albumin, transferrin and peptides such as stable microbial toxins and cell penetrating peptides (CPPs) as innovative tumor targeting ligands in anticancer drug delivery systems.do...
Combinatorial methods are being used to engineer knottins that can bind to other clinically relevant targets in cancer, and inflammatory and cardiac disease. This review details recent examples of engineered knottin peptides; their use as molecular imaging agents, therapeutics, and drug delivery ...
Rights and permissions Reprints and permissions About this article Cite this article Mookherjee, N., Anderson, M.A., Haagsman, H.P. et al. Antimicrobial host defence peptides: functions and clinical potential. Nat Rev Drug Discov 19, 311–332 (2020). https://doi.org/10.1038/s41573-019...
Chemotherapeutic drugs invariably induce significant cytotoxic side effects in cancer patients and often lead to the expansion of drug-resistant clones. Considerable efforts have been invested over recent years in developing drug delivery systems aimed at limiting drug activity to the target cell. Achievin...
Self-assembled peptides have shown outstanding characteristics for vaccine delivery and drug targeting. Peptide molecules can be rationally designed to self-assemble into specific nanoarchitectures in response to changes in their assembly environment including: pH, temperature, ionic strength, and interactions...
1.A drug delivery system comprising: (a) a cell targeting domain that is a region that specifically binds to a target molecule of a target cell; and (b) a pH-dependent cell-penetrating peptide bound to the cell targeting domain.
The present technology relates generally to the field of cationic peptide drugs and peptide drug delivery systems. The compositions of such systems include a unimolecular nanoparticle and cationic peptide drug(s). SUMMARY OF THE INVENTION Metabolic reprogramming is a hallmark of cancer. The inventors ...