We found that IFNγ-induced PD-L1 overexpression is mediated by activation of JAK2/STAT1/IRF-1 signaling pathway in EBV (+) GC. Although IFNγ has been previously demonstrated to increase PD-L1 expression in GC cells27, the detailed mechanisms by which IFNγ induces PD-L1 expression in EBV...
Overexpression of HK2 and enhanced aerobic glycolysis have been detected in many types of cancer , and systemic HK2 ablation in genetic mouse models inhibited tumor development . While aerobic glycolysis supports rapid ATP synthesis, anabolic processes, and NADPH through the pentose phosphate pathway, w...
Prognostic value of PD-L1 overexpression for pancreatic cancer: evidence from a meta-analysis 来自 NCBI 喜欢 0 阅读量: 104 作者:ZS Yongxun,F Huang,M Feng,X Zhao,W Chen,Z Zhu,S Zhang 摘要: Programmed death-ligand 1 (PD-L1) is an immune checkpoint that is often activated in cancer and...
Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants. Oncotarget. 2016;7(22):32318-32328. DOI: 10.18632/oncotarget.8698 Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung...
194Citations 18Altmetric Metrics Abstract Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to...
Walfish PG. Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants. Oncotarget. 2016 May 31;7(22):32318-28. [24] Rosenbaum MW, Bledsoe JR, Morales-Oyarvide V, Huynh TG, Mino-Kenudson ...
(PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has...
OkitaR, MaedaA, ShimizuK, et al.PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer[J].Cancer Immunol Immunother, 2017, 66(7): 865-876.DOI:10.1007/...
尽管并不特异,但这一结果可能预示着肿瘤细胞PD-L1具有构成性过表达(constitutive overexpression)。 图3. 心包积液中的腺癌,抗体22C3检测,肿瘤细胞具有PD-L1的表达。 图4. 抗体22C3检测,肿瘤内PD-L1免疫着色强度不均一,该图中0至3+结果均有。 图5. PD-L1检测中,部分细胞膜着色,腔面并无着色,这种情况仍视...
Okita, R.et al. PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer.Cancer Immunol Immunother66, 865–876 (2017). ArticleCASPubMedGoogle Scholar ...