Furthermore, to modulate PD-L1 expression, we treated HepG2, SK-Hep1, and sorafenib-resistant SK-Hep1R cells with rapamycin. Here, we found thatglucose deprivation reduced PD-L1 expression in HCC cells. Additionally,TCGA data and immunostaining analyses confirmed a positive correlation between ...
题为”PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma”(循环肿瘤细胞上PD-L1的表达可作为PD-1抑制剂联合放射治疗和抗血管生成治疗晚期肝细胞癌的预测生物标志物),旨在确定程...
PD-L1 expression in neuroendocrine tumors of the lung. Lung Cancer. Jun 2017;108:115-120. 7.Yasuda Y, Ozasa H, Kim YH. PD-L1 Expression in Small Cell Lung Cancer. J Thorac Oncol. Mar 2018;13(3):e40-e41. 8.Sheng X, Yan X, Chi Z,...
肝细胞癌中PD-L1表达和体细胞突变图谱(The landscape of PD-L1 expression and somatic mutations in hepatocellular carcinoma ) 内容亮点 肝细胞癌(HCC)是肝脏最常见的原发性恶性肿瘤,并成为全球癌症相关死亡的第三大原因。尽管免疫检查点...
2023). The activation of the mammalian target of rapamycin (mTOR) pathway in p53-loss-of-function HCC cells was found to enhance PD-L1 expression, further supporting the role of PD-L1 in immune evasion.Role of PD-L1 in Tumor Progression...
2、作者描述了PD-L1的各种翻译后修饰的作用,包括磷酸化、糖基化、乙酰化和泛素化。此外,还讨论了小分子药物调节这些机制的潜在用途。 中国医药大学校长洪明奇(Mien-Chie Hung)教授课题组在国际知名期刊Nat Rev Clin Oncol在线发表题为“Mechanisms regulating PD-L1 expression in cancers and associated opportunities ...
Han Z, Wang N, Qiao Q, He X, Wang N. Association of PD-L1 Expression with Clinicopathologic Characters in Gastric Cancer: A Comprehensive Meta-analysis. Curr Med Chem. 2024;31(21):3198-3216. 结论 纳武利尤单抗联合伊匹木单抗是一种针对不可切除肝细胞癌(HCC)的新型一线治疗方案,具有非常高的疗效...
4月7日,最新发表在Science Translational Medicine杂志上的一项研究中,来自香港中文大学的一个科学家团队证实,在肝细胞癌(HCC)中,选择性HDAC8抑制剂能够增强抗肿瘤免疫力以及PD-L1抗体的疗效[3]。 具体来说,在该研究中,科学家们首先在两种同基因和原位HCC模型中调查了一种高度特异性HDAC8抑制剂——PCI-34051。研...
《Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy》《PD-L1 expression by dendritic cells is a keyregulator of T-cell immunity in cancer》文献1 Science的子刊《Science Translational Medicine》PD-L1/PD-1阻断抗体已证明对一系列人类癌症具有治疗效果。然而，将这种益处扩大到更多的...
《PD-L1 expression by dendritic cells is a keyregulator of T-cell immunity in cancer》 文献1 Science的子刊《Science Translational Medicine》 PD-L1/PD-1阻断抗体已证明对一系列人类癌症具有治疗效果。然而,将这种益处扩大到更多的患者,需要更好地了解这些疗法如何激发抗癌免疫。虽然PD-L1/PD-1轴通常与T细胞...