外泌体(exosome)是由活细胞分泌的直径约为40-160 nm的小囊泡,具有典型的脂质双分子层结构。包含有细胞的许多成分组成,包括DNA、RNA、氨基酸、蛋白质、代谢物、酶、脂质(胆固醇)和热休克蛋白,以及一些参与细胞间通讯的胞质和细胞表面信号蛋白等。胞外体膜富含跨膜蛋白(如CD81、CD63和CD9等四肽)、整合素和粘附分...
01外泌体与肿瘤生长和侵袭相关 外泌体(exosome)是由活细胞分泌的直径约为40-160 nm的小囊泡,具有典型的脂质双分子层结构。包含有细胞的许多成分组成,包括DNA、RNA、氨基酸、蛋白质、代谢物、酶、脂质(胆固醇)和热休克蛋白,以及一些参与细胞间通讯的胞质和细胞表面信号蛋白等。胞外体膜富含跨膜蛋白(如CD81、CD63...
PD-L1ExosomeFracture healingHydrogelImmunotherapyA moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted th...
exosomes with anti-PD-L1 neutralizing antibody. H460 cell-derived and H1975 cell-derived exosomes with high PD-L1 levels significantly reversed the exosome-induced reduction of INF-γ production (Fig.3a), whereas A549 cell-derived exosomes with low PD-L1 levels did not. To confirm these findin...
[2]Xinyi Tu et al. PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy. Molecular Cell(2019). 参考资料: 1#Research decode...
3.外泌体(exosome)是一种由活细胞分泌的,直径约为40～160nm的具有双层膜结构的生物活性囊泡。它携带了分泌细胞包含的生物活性物质。作为潜在的肿瘤标志物,外泌体在诸如血液、尿液等的体液中相当稳定,可以分离出来用于临床评估,甚至在疾病早期也可以检测到。外泌体上一些特定蛋白质的表达量,如pd-l1,磷脂酰肌醇聚糖...
此前研究发现,肿瘤组织内部的巨噬细胞导致免疫抑制,促进肿瘤生长,但是具体机制未知。来自美国宾夕法尼亚大学的Wei Guo课题组在《Cell Reports》发表论文,揭示肿瘤相关巨噬细胞分泌大量外泌体,表面携带的PD-L1导致免疫抑制,降低T细胞浸润和活化,从而促进肿瘤生长。 (文献题目:Upregulation of exosome secretion from tu...
1.Effectsof Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity andClinical Applications. Front Cell Dev Biol. 2021; 9: 760211. 公众号已建立“小药-生物资源对接服务平台”微信行业交流群以及读者交流群,扫描下方小编二维码加入,入行业群请主动告知姓名、工作...
Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment Masoud Lahouty Manouchehr Fadaee Tohid Kazemi Molecular Biology Reports (2025) Extracellular vesicles in cancer cachexia: deciphering pathogenic roles and exploring therapeutic horizons Yifeng Wang Shengguang Ding Journal of Tran...
4. Bo Shao, et al. Effectsof Tumor-Derived ExosomeProgrammed Death Ligand 1 on Tumor Immunity andClinical Applications. FrontCell Dev Biol. 2021; 9: 760211. 5. Dhouha Daassi , et al. The importance of exosomal PD-L1intumour immune evasion.Nat Rev Immunol. 2020 Apr;20(4):209-215. ...