PD‐1/PD‐L1 axistumor immune escapetumor‐derived exosomesProgrammed cell death(PD is a negative coreceptor mainly expressed on the surface of activated T cells. The binding of PDto its ligand PD㎜1 significantly induces non‐reactivity of T cells to maintain the balance of autoimmunity and ...
Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the metastatic site16. Exosomes derived from tumors and stromal cells have been involved in all stages of cancer metastasis. In addition to the different types of substances loaded in e...
Tumor-Derived PD-L1+ Exosomes with Natural Inflammation Tropism for Psoriasis-Targeted TreatmentPsoriasis is a chronic inflammatory disease whose etiology is ... Honglin Jia,Tao Liu,Qunfang Yang,... 被引量: 0发表: 0年 513. Armed-Ad Gene Therapy Expressing PD-L1 Minibody Enhances the Anti-Tum...
Through exosomes, TAMs regulate the tumorigenesis through crosstalk between various immune cells in the TME [11]. TAMs-derived exosomes carry non-coding RNAs (ncRNAs), proteins, and lipids that regulate malignant cell proliferation, invasion, metastasis, angiogenesis, immune response, drug resistance, ...
Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of c
[53] reported that monocytes can preferentially and rapidly absorb glioblastoma stem cell-derived exosomes, releasing multiple factors, particularly STAT3—a key molecular hub for tumor-mediated immunosuppression—thereby promoting the expression of programmed death ligand 1 (PD-L1) and polarization into ...
Recent researches have indicated that exosomes derived from cancer cells also express PD-L1. PD-L1+ exosomes can impair immune functions and promote tumor growth in the similar way as above, which may also result in a low response to anti-PD-L1 therapy. Therefore, targeting the PD-L1 ...
Regulation of metabolism by tumor-derived exosomes. Tumor-derived exosomes (TDEs) carrying specific substances are secreted after intracellular ESCRT machinery. TDEs act on CAFs to promote glycolysis by up-regulating GLU1 expression and down-regulating Cav1 expression. Then CAF-derived exosomes (CDEs)...
migration and invasion by raising MMP2 expression [66]. Earlier studies have shown that fibroblasts treated by melanoma-derived exosomes demonstrate higher cell invasion potential [67]. These events were attributed to the release of miR-21, contained into TDSEVs, resulting in upregulated expression ...
derived exosomes and their influence on cancer cells. TAMs have two opposing phenotypes; macrophages exhibiting pro-tumorigenic activity are termed M2-type macrophages, in contrast to the antitumorigenic M1 subtype. The phenotype of TAMs is regulated by specific tumor-derived chemokines and exosomes. ...