2018年8月8号,又一篇关于外泌体的重磅报道“Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response”发表在顶级期刊《Nature》上,为“癌症如何在全身对抗免疫系统”这一难题带来了颠覆性认识。 文中证实了黑色素瘤细胞分泌的外泌体中带有PD-L1蛋白,并且可以直接与T细胞结合,...
2018年8月8号,又一篇关于外泌体的重磅报道“Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response”发表在顶级期刊《Nature》上,为“癌症如何在全身对抗免疫系统”这一难题带来了颠覆性认识。 文中证实了黑色素瘤细胞分泌的外泌体中带有PD-L1蛋白,并且可以直接与T细胞结合,...
对肾癌细胞PD-L1的诱导表达.结果PBRM1在肾透明细胞癌肿瘤中的组织表达量显著低于癌旁组织(P<0.001),患者肿瘤组织PBRM1表达缺失率高达76.4%.肾透明细胞癌组织芯片免疫组化和TCGA数据库结果显示PBRM1表达与PD-L1表达没有相关性,TCGA数据库及分子生物学实验证实PBRM1突变后激活TNF-α/exosome信号通路增加PD-L1蛋白含量,...
seriously affecting patient quality of life [1]. HCC is a highly fatal tumor that is usually found in the advanced stage [2]. In recent years, immune checkpoint blocking (ICB) therapy, specifically antibodies against programmed cell death 1 (PD1)/ programmed cell death-Ligand 1 (PD-L1) sig...
1.帕金森(PD) 帕金森病的特征是中脑多巴胺能神经元的快速丧失。使用人胚胎干细胞治疗帕金森的第一次尝试是通过生成多巴胺能样神经元,后来有人提出多能干细胞(ipscs)作为克服 胚胎干细胞(ESC)争议的替代方法。在2018年8月,山中伸弥(Shinya Yamanka)启动了首个批准的使用iPSCs治疗PD的临床试验。共招募了7例中度PD...
上海玉博生物科技有限公司 主要致力于“PIERCEMA112584Anti-Exosome component 1 Monoclonal Antibody100 µg 100 µg”的生产销售。多年的“PIERCEMA112584Anti-Exosome component 1 Monoclonal Antibody100 µg 100 µg”生产与销售的经验,与各行业新老用户建立
(PD), Huang et al. discovered that MSC exosomes-derived TSG6 with anti-inflammatory and anti-oxidative stress properties, could ease neurotoxicity in an in vitro PD model using SH-SY5Y and SK-N-SH cells [129]. In addition, the therapeutic effect was confirmed to be achieved through the ...
PD-1 RECEPTOR AND LIGANDS ARE CONCENTRATED IN THE EXOSOME FRACTION OF HUMAN OVARIAN FOLLICULAR FLUIDdoi:10.1016/j.fertnstert.2020.08.316Thanh Ha LuuEvelyn Mercedes Llerena CariJohn RushingLiesl Nel-ThemaatJoshua JohnsonFertility and Sterility
Moreover, the promising PD-L1 expression was identified on the exosomes, which potently suppressed Tfh cell polarization via inhibiting the PI3K/AKT pathway. Importantly, Exos@SFMA effectively relieved synovial inflammation and joint destruction by significantly reducing T follicular helper (Tfh) cell ...
CircCCAR1 is secreted by HCC cells in a heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1)-dependent manner. Exosomal circCCAR1 was taken in by CD8 + T cells and caused dysfunction of CD8 + T cells by stabilizing the PD-1 protein. CircCCAR1 promoted resistance to anti-PD1 ...