189]. Recent studies have shown that CAR-T cell-derived exosomes as a cell-free therapy not only retain most of the functions of CAR-T cells but also have greater therapeutic efficiency, higher controllability, lower toxicity, and
Exosomal circCCAR1 released by HCC cells contributes to immunosuppression by facilitating CD8 + T-cell dysfunction in HCC. CircCCAR1 induces resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for HCC patients.doi:10.1186/s12943-023-01759-1Hu, Zongqiang...
Full size image It is known that tumor cells release more exosomes than normal cells and also the surface of TDE contains membrane proteins such as Epidermal growth factor receptor (EGFR), CD317, CD91, in conjunction with possibly PD-L1, which could be a potential tumor marker [14,15]. O...
rebuilding the TAMs landscape gains increasing attention. Various approaches can achieve it, blocking different surface molecules involved in the immunosuppressive profile of TAMs like PD1-PDL1, CD206, CD63, CD
(PD1)/ programmed cell death-Ligand 1 (PD-L1) signaling, has been widely used in cancer, which greatly prolongs the survival time of cancer patients [3]. A PD1 antibody has been approved for second-line therapy in advanced HCC [4]. However, only 17–18% of advanced HCC patients have ...
取出2感染好的2盘细胞,迅速用5ml PBS/遍 洗涤3遍,加入1ml胰酶, 摇匀使每个细胞都孵育胰酶,37°C静置消化1min,加入4ml Exosome-free的10%血清的DMEM静置,获得5ml细胞悬液,加入到准备好的10盘10cm盘中,获得5盘GFP、5盘plv-cs2.0-myc-PD1稳转293T 细胞系,37°C培养48h; 3.取4根灭菌处理过的50ml管,收集...
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. Mol Cancer. 2023;22(1):55. Article CAS PubMed PubMed Central Google Scholar Yang R, Chen H, Xing L, Wang B, Hu M, Ou X, Chen H, Deng Y, Liu D, Jiang R, Chen...
L1 and CD28 in NSCLC patients receiving ICIs demonstrated that patients with elevated levels of exo-PD-L1 and decreased levels of CD28 had shorter progression-free survivals implying that aggregate baseline levels of exoPD-L1 and CD28 could be of predictive significance of anti-PD1 therapy [57]....
The malignant form of melanoma is one of the deadliest human cancers that accounts for almost all of the skin tumor-related fatalities in its later stages. Achieving an exhaustive understanding of reliable cancer-specific markers and molecular pathways c
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. Mol Cancer. 2023;22(1):55. Article CAS PubMed PubMed Central Google Scholar Paskeh MDA, Entezari M, Mirzaei S, et al. Emerging role of exosomes in cancer progression and ...